来自线纹香茶菜的具有细胞毒性和抗炎作用的对映-贝壳杉烷二萜类化合物。

Cytotoxic and anti-inflammatory ent-kaurane diterpenoids from Isodon wikstroemioides.

作者信息

Wu Hai-Yan, Wang Wei-Guang, Jiang Hua-Yi, Du Xue, Li Xiao-Nian, Pu Jian-Xin, Sun Han-Dong

机构信息

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China; University of Chinese Academy of Sciences, Beijing 100049, PR China.

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China.

出版信息

Fitoterapia. 2014 Oct;98:192-8. doi: 10.1016/j.fitote.2014.08.012. Epub 2014 Aug 12.

DOI:10.1016/j.fitote.2014.08.012

PMID:25128423

Abstract

Seven new ent-kaurane diterpenoids, isowikstroemins A-G (1-7), were isolated from EtOAc extracts of the aerial parts of Isodon wikstroemioides. Their structures were elucidated by extensive spectroscopic analysis. The isolates were evaluated for their cytotoxicity against five human tumor cell lines, and compounds 1-4 exhibited significant activity with IC50 values ranging from 0.9 to 7.0 μM. In addition, compounds 1, 2, 3, 4, and 7 exhibited inhibitory activity against nitric oxide (NO) production in LPS-activated RAW264.7 macrophages.

摘要

从线纹香茶菜地上部分的乙酸乙酯提取物中分离出7个新的对映-贝壳杉烷二萜类化合物，即异柳杉素A-G（1-7）。通过广泛的光谱分析确定了它们的结构。评估了这些分离物对5种人类肿瘤细胞系的细胞毒性，化合物1-4表现出显著活性，IC50值在0.9至7.0 μM之间。此外，化合物1、2、3、4和7对脂多糖激活的RAW264.7巨噬细胞中一氧化氮（NO）的产生具有抑制活性。