大鼠某些组织中腺苷脱氨酶的分布。乙醇和二甲基亚砜的抑制作用。
Distribution of adenosine deaminase in some rat tissues. Inhibition by ethanol and dimethyl sulfoxide.
作者信息
Centelles J J, Franco R, Bozal J
出版信息
Comp Biochem Physiol B. 1987;86(1):95-8. doi: 10.1016/0305-0491(87)90180-5.
The level of adenosine deaminase in various rat tissues has been tested. The enzyme activity of cytosolic fractions decreased in the following order: lung greater than spleen greater than small intestine greater than stomach greater than kidney greater than heart greater than liver greater than skeletal muscle greater than forebrain greater than cerebellum. The enzyme had identical patterns from tissue to tissue with respect to Km, V, and Ki values for ethanol and for dimethyl sulfoxide, with respect to electrophoretic behaviour and to inhibition by antibodies anti-rat brain adenosine deaminase.
已对各种大鼠组织中的腺苷脱氨酶水平进行了检测。胞质部分的酶活性按以下顺序降低：肺＞脾＞小肠＞胃＞肾＞心脏＞肝脏＞骨骼肌＞前脑＞小脑。该酶在不同组织之间，在乙醇和二甲基亚砜的米氏常数（Km）、最大反应速度（V）和抑制常数（Ki）值方面，在电泳行为方面，以及在抗大鼠脑腺苷脱氨酶抗体的抑制作用方面，具有相同的模式。
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