Bioorganic Laboratory, Department of Chemistry, University of Delhi, Delhi, 110007, India.
Department of Chemistry, Daulat Ram College, University of Delhi, Delhi, 110007, India.
Top Curr Chem (Cham). 2024 Jan 31;382(1):4. doi: 10.1007/s41061-024-00451-2.
Pyrimidine is a pharmacologically important moiety that exhibits diverse biological activities. This review reflects the growing significance of transition metal-catalyzed reactions for the synthesis of pyrimidines (with no discussion being made on the transition metal-catalyzed functionalization of pyrimidines). The effect of different catalysts on the selectivity/yields of pyrimidines and catalyst recyclability (wherever applicable) are described, together with attempts to illustrate the role of the catalyst through mechanisms. Although several methods have been researched for synthesizing this privileged scaffold, there has been a considerable push to expand transition metal-catalyzed, sustainable, efficient and selective synthetic strategies leading to pyrimidines. The aim of the authors with this update (2017-2023) is to drive the designing of new transition metal-mediated protocols for pyrimidine synthesis.
嘧啶是一种具有重要药理学意义的杂环，具有多种生物活性。本综述反映了过渡金属催化反应在嘧啶合成中的重要性日益增加（未讨论过渡金属催化的嘧啶官能化）。描述了不同催化剂对嘧啶选择性/产率的影响以及催化剂的可回收性（在适用的情况下），并通过机理试图说明催化剂的作用。尽管已经研究了几种合成这种优势支架的方法，但人们一直在大力推动开发过渡金属催化的可持续、高效和选择性的合成策略来合成嘧啶。作者在本次更新（2017-2023 年）中的目的是推动设计新的过渡金属介导的嘧啶合成方法。
