Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA.
Transl Psychiatry. 2024 Jan 31;14(1):69. doi: 10.1038/s41398-023-02719-5.
Hippocampal volume is smaller in schizophrenia, but it is unclear when in the illness the changes appear and whether specific regions (anterior, posterior) and subfields (CA1, CA2/3, dentate gyrus, subiculum) are affected. Here, we used a high-resolution T2-weighted sequence specialized for imaging hippocampal subfields to test the hypothesis that anterior CA1 volume is lower in early psychosis. We measured subfield volumes across hippocampal regions in a group of 90 individuals in the early stage of a non-affective psychotic disorder and 70 demographically similar healthy individuals. We observed smaller volume in the anterior CA1 and dentate gyrus subfields in the early psychosis group. Our findings support models that implicate anterior CA1 and dentate gyrus subfield deficits in the mechanism of psychosis.
海马体体积在精神分裂症中较小，但尚不清楚疾病何时出现变化，以及特定区域（前、后）和亚区（CA1、CA2/3、齿状回、下托）是否受到影响。在这里，我们使用了一种专门用于成像海马亚区的高分辨率 T2 加权序列，来测试早期精神病中前 CA1 体积较低的假设。我们在一组 90 名非情感性精神病早期阶段的个体和 70 名在人口统计学上相似的健康个体中测量了海马区域的亚区体积。我们观察到早期精神病组中前 CA1 和齿状回亚区的体积较小。我们的研究结果支持了涉及前 CA1 和齿状回亚区缺陷的精神病发病机制模型。
