Johns K J, O'Day D M, Head W S, Neff R J, Elliott J H
Curr Eye Res. 1987 Jan;6(1):207-12. doi: 10.3109/02713688709020092.
Acanthamoeba is a free-living, fresh-water protozoan that can cause severe corneal disease. Acanthamoeba keratitis can closely mimic epithelial and stromal Herpes simplex keratitis. Three cases of severe keratitis, were referred for treatment. One patient presented with a pseudodendritic epithelial lesion that gradually progressed to stromal involvement. A second patient presented with central stromal infiltrate and necrosis, while a third exhibited features of a disciform lesion with the later development of an immune ring. Acanthamoeba was recovered from the cornea in each case. The distinctive characteristics of the history and clinical findings in Acanthamoeba keratitis can aid the clinician in distinguishing between these two clinical entities. Cytopathology and special staining and culture techniques can confirm the diagnosis.
棘阿米巴是一种自由生活的淡水原生动物，可导致严重的角膜疾病。棘阿米巴角膜炎可与单纯疱疹病毒性上皮性和基质性角膜炎极为相似。有3例严重角膜炎患者前来就诊。1例患者出现假树枝状上皮病变，逐渐发展至基质受累。第2例患者表现为中央基质浸润和坏死，而第3例表现为盘状病变特征，随后出现免疫环。每例患者的角膜均分离出棘阿米巴。棘阿米巴角膜炎病史和临床发现的独特特征有助于临床医生区分这两种临床病症。细胞病理学、特殊染色和培养技术可确诊。
