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减重手术类型对心脏逆重构的影响。

The effect of bariatric surgery type on cardiac reverse remodelling.

机构信息

Oxford Centre for Clinical Magnetic Resonance Research, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.

Aix-Marseille University, CNRS, CRMBM, Marseille, France.

出版信息

Int J Obes (Lond). 2024 Jun;48(6):808-814. doi: 10.1038/s41366-024-01474-x. Epub 2024 Jan 31.


DOI:10.1038/s41366-024-01474-x
PMID:38297029
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11129945/
Abstract

INTRODUCTION: Bariatric surgery is effective in reversing adverse cardiac remodelling in obesity. However, it is unclear whether the three commonly performed operations; Roux-en-Y Gastric Bypass (RYGB), Laparoscopic Sleeve Gastrectomy (LSG) and Laparoscopic Adjustable Gastric Band (LAGB) are equal in their ability to reverse remodelling. METHODS: Fifty-eight patients underwent CMR to assess left ventricular mass (LVM), LV mass:volume ratio (LVMVR) and LV eccentricity index (LVei) before and after bariatric surgery (26 RYGB, 22 LSG and 10 LAGB), including 46 with short-term (median 251-273 days) and 43 with longer-term (median 983-1027 days) follow-up. Abdominal visceral adipose tissue (VAT) and epicardial adipose tissue (EAT) were also assessed. RESULTS: All three procedures resulted in significant decreases in excess body weight (48-70%). Percentage change in VAT and EAT was significantly greater following RYGB and LSG compared to LAGB at both timepoints (VAT:RYGB -47% and -57%, LSG -47% and -54%, LAGB -31% and -25%; EAT:RYGB -13% and -14%, LSG -16% and -19%, LAGB -5% and -5%). Patients undergoing LAGB, whilst having reduced LVM (-1% and -4%), had a smaller decrease at both short (RYGB: -8%, p < 0.005; LSG: -11%, p < 0.0001) and long (RYGB: -12%, p = 0.009; LSG: -13%, p < 0.0001) term timepoints. There was a significant decrease in LVMVR at the long-term timepoint following both RYGB (-7%, p = 0.006) and LSG (-7%, p = 0.021), but not LAGB (-2%, p = 0.912). LVei appeared to decrease at the long-term timepoint in those undergoing RYGB (-3%, p = 0.063) and LSG (-4%, p = 0.015), but not in those undergoing LAGB (1%, p = 0.857). In all patients, the change in LVM correlated with change in VAT (r = 0.338, p = 0.0134), while the change in LVei correlated with change in EAT (r = 0.437, p = 0.001). CONCLUSIONS: RYGB and LSG appear to result in greater decreases in visceral adiposity, and greater reverse LV remodelling with larger reductions in LVM, concentric remodelling and pericardial restraint than LAGB.

摘要

简介:减重手术可有效逆转肥胖患者的心脏不良重构。然而,目前尚不清楚三种常见手术(Roux-en-Y 胃旁路术(RYGB)、腹腔镜袖状胃切除术(LSG)和腹腔镜可调胃束带术(LAGB))在逆转重构方面的能力是否相同。 方法:58 名患者接受心脏磁共振(CMR)检查,以评估减重手术前后左心室质量(LVM)、LV 质量:体积比(LVMVR)和 LV 偏心指数(LVei),其中包括 46 名短期(中位数 251-273 天)和 43 名长期(中位数 983-1027 天)随访患者。还评估了腹部内脏脂肪组织(VAT)和心外膜脂肪组织(EAT)。 结果:三种手术均导致超重体重显著下降(48-70%)。RYGB 和 LSG 术后 VAT 和 EAT 的百分比变化明显大于 LAGB(VAT:RYGB -47%和-57%,LSG -47%和-54%,LAGB -31%和-25%;EAT:RYGB -13%和-14%,LSG -16%和-19%,LAGB -5%和-5%)。接受 LAGB 的患者尽管 LVM 减少(-1%和-4%),但在短期(RYGB:-8%,p<0.005;LSG:-11%,p<0.0001)和长期(RYGB:-12%,p=0.009;LSG:-13%,p<0.0001)时间点的减少幅度较小。RYGB(-7%,p=0.006)和 LSG(-7%,p=0.021)在长期时间点上 LVMVR 明显下降,但 LAGB 无此变化(-2%,p=0.912)。在接受 RYGB 和 LSG 的患者中,LVei 似乎在长期时间点下降(RYGB:-3%,p=0.063;LSG:-4%,p=0.015),但在接受 LAGB 的患者中没有(1%,p=0.857)。所有患者的 LVM 变化与 VAT 变化相关(r=0.338,p=0.0134),而 LVei 变化与 EAT 变化相关(r=0.437,p=0.001)。 结论:RYGB 和 LSG 似乎可导致内脏脂肪量更大减少,并导致更大的 LV 重构逆转,LV 质量、向心性重构和心包约束的减少幅度大于 LAGB。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a01d/11129945/882966a4276d/41366_2024_1474_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a01d/11129945/b912a0df31db/41366_2024_1474_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a01d/11129945/7d6ed30d019b/41366_2024_1474_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a01d/11129945/882966a4276d/41366_2024_1474_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a01d/11129945/b912a0df31db/41366_2024_1474_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a01d/11129945/7d6ed30d019b/41366_2024_1474_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a01d/11129945/882966a4276d/41366_2024_1474_Fig3_HTML.jpg

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引用本文的文献

[1]
Fluctuations of epicardial adipose tissue and cardiovascular health: A useful biomarker? A comprehensive review.

J Cardiovasc Thorac Res. 2025-6-28

[2]
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Eur Heart J. 2025-4-8

[3]
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本文引用的文献

[1]
Triple-Hormone-Receptor Agonist Retatrutide for Obesity - A Phase 2 Trial.

N Engl J Med. 2023-8-10

[2]
Adipo-cardiology: The next frontier in cardiovascular disease.

Prog Cardiovasc Dis. 2023

[3]
Changes in epicardial and visceral adipose tissue depots following bariatric surgery and their effect on cardiac geometry.

Front Endocrinol (Lausanne). 2023

[4]
Long-Term Changes in Cardiac Structure and Function Following Bariatric Surgery.

J Am Coll Cardiol. 2022-10-18

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Obesity and heart failure with preserved ejection fraction: new insights and pathophysiological targets.

Cardiovasc Res. 2023-2-3

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N Engl J Med. 2022-7-21

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Obesity (Silver Spring). 2022-3

[8]
Uncoupling between intravascular and distending pressures leads to underestimation of circulatory congestion in obesity.

Eur J Heart Fail. 2022-2

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Adverse right ventricular remodelling, function, and stress responses in obesity: insights from cardiovascular magnetic resonance.

Eur Heart J Cardiovasc Imaging. 2022-9-10

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Metabolism. 2021-6

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