Oxford Centre for Clinical Magnetic Resonance Research, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Aix-Marseille University, CNRS, CRMBM, Marseille, France.
Int J Obes (Lond). 2024 Jun;48(6):808-814. doi: 10.1038/s41366-024-01474-x. Epub 2024 Jan 31.
INTRODUCTION: Bariatric surgery is effective in reversing adverse cardiac remodelling in obesity. However, it is unclear whether the three commonly performed operations; Roux-en-Y Gastric Bypass (RYGB), Laparoscopic Sleeve Gastrectomy (LSG) and Laparoscopic Adjustable Gastric Band (LAGB) are equal in their ability to reverse remodelling. METHODS: Fifty-eight patients underwent CMR to assess left ventricular mass (LVM), LV mass:volume ratio (LVMVR) and LV eccentricity index (LVei) before and after bariatric surgery (26 RYGB, 22 LSG and 10 LAGB), including 46 with short-term (median 251-273 days) and 43 with longer-term (median 983-1027 days) follow-up. Abdominal visceral adipose tissue (VAT) and epicardial adipose tissue (EAT) were also assessed. RESULTS: All three procedures resulted in significant decreases in excess body weight (48-70%). Percentage change in VAT and EAT was significantly greater following RYGB and LSG compared to LAGB at both timepoints (VAT:RYGB -47% and -57%, LSG -47% and -54%, LAGB -31% and -25%; EAT:RYGB -13% and -14%, LSG -16% and -19%, LAGB -5% and -5%). Patients undergoing LAGB, whilst having reduced LVM (-1% and -4%), had a smaller decrease at both short (RYGB: -8%, p < 0.005; LSG: -11%, p < 0.0001) and long (RYGB: -12%, p = 0.009; LSG: -13%, p < 0.0001) term timepoints. There was a significant decrease in LVMVR at the long-term timepoint following both RYGB (-7%, p = 0.006) and LSG (-7%, p = 0.021), but not LAGB (-2%, p = 0.912). LVei appeared to decrease at the long-term timepoint in those undergoing RYGB (-3%, p = 0.063) and LSG (-4%, p = 0.015), but not in those undergoing LAGB (1%, p = 0.857). In all patients, the change in LVM correlated with change in VAT (r = 0.338, p = 0.0134), while the change in LVei correlated with change in EAT (r = 0.437, p = 0.001). CONCLUSIONS: RYGB and LSG appear to result in greater decreases in visceral adiposity, and greater reverse LV remodelling with larger reductions in LVM, concentric remodelling and pericardial restraint than LAGB.
简介:减重手术可有效逆转肥胖患者的心脏不良重构。然而,目前尚不清楚三种常见手术(Roux-en-Y 胃旁路术(RYGB)、腹腔镜袖状胃切除术(LSG)和腹腔镜可调胃束带术(LAGB))在逆转重构方面的能力是否相同。 方法:58 名患者接受心脏磁共振(CMR)检查,以评估减重手术前后左心室质量(LVM)、LV 质量:体积比(LVMVR)和 LV 偏心指数(LVei),其中包括 46 名短期(中位数 251-273 天)和 43 名长期(中位数 983-1027 天)随访患者。还评估了腹部内脏脂肪组织(VAT)和心外膜脂肪组织(EAT)。 结果:三种手术均导致超重体重显著下降(48-70%)。RYGB 和 LSG 术后 VAT 和 EAT 的百分比变化明显大于 LAGB(VAT:RYGB -47%和-57%,LSG -47%和-54%,LAGB -31%和-25%;EAT:RYGB -13%和-14%,LSG -16%和-19%,LAGB -5%和-5%)。接受 LAGB 的患者尽管 LVM 减少(-1%和-4%),但在短期(RYGB:-8%,p<0.005;LSG:-11%,p<0.0001)和长期(RYGB:-12%,p=0.009;LSG:-13%,p<0.0001)时间点的减少幅度较小。RYGB(-7%,p=0.006)和 LSG(-7%,p=0.021)在长期时间点上 LVMVR 明显下降,但 LAGB 无此变化(-2%,p=0.912)。在接受 RYGB 和 LSG 的患者中,LVei 似乎在长期时间点下降(RYGB:-3%,p=0.063;LSG:-4%,p=0.015),但在接受 LAGB 的患者中没有(1%,p=0.857)。所有患者的 LVM 变化与 VAT 变化相关(r=0.338,p=0.0134),而 LVei 变化与 EAT 变化相关(r=0.437,p=0.001)。 结论:RYGB 和 LSG 似乎可导致内脏脂肪量更大减少,并导致更大的 LV 重构逆转,LV 质量、向心性重构和心包约束的减少幅度大于 LAGB。
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