Ruperez Celia, Madeo Frank, de Cabo Rafael, Kroemer Guido, Abdellatif Mahmoud
Department of Cardiology, Medical University of Graz, Auenbruggerplatz 15, Graz 8036, Austria.
Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria.
Eur Heart J. 2025 Apr 8. doi: 10.1093/eurheartj/ehaf216.
A global obesity pandemic, coupled with an increasingly ageing population, is exacerbating the burden of cardiovascular disease. Indeed, clinical and experimental evidence underscores a potential connection between obesity and ageing in the pathogenesis of various cardiovascular disorders. This is further supported by the notion that weight reduction not only effectively reduces major cardiovascular events in elderly individuals but is also considered the gold standard for lifespan extension, in obese and non-obese model organisms. This review evaluates the intricate interplay between obesity and ageing from molecular mechanisms to whole organ function within the cardiovascular system. By comparatively analysing their characteristic features, shared molecular and cell biological signatures between obesity and ageing are unveiled, with the intent to shed light on how obesity accelerates cardiovascular ageing. This review also elaborates on how emerging metabolic interventions targeting obesity might protect from cardiovascular diseases largely through antagonizing key molecular mechanisms of the ageing process itself. In sum, this review aims to provide valuable insight into how understanding these interconnected processes could guide the development of novel and effective cardiovascular therapeutics for a growing aged population with a concerning obesity problem.
全球肥胖流行，加之人口老龄化加剧，正在加重心血管疾病的负担。事实上，临床和实验证据强调了肥胖与衰老在各种心血管疾病发病机制中的潜在联系。这一观点进一步得到以下观点的支持：体重减轻不仅能有效降低老年个体的主要心血管事件，而且在肥胖和非肥胖模式生物中，体重减轻也被视为延长寿命的黄金标准。本综述评估了肥胖与衰老在心血管系统内从分子机制到全器官功能的复杂相互作用。通过比较分析它们的特征，揭示了肥胖与衰老之间共同的分子和细胞生物学特征，旨在阐明肥胖如何加速心血管衰老。本综述还阐述了针对肥胖的新兴代谢干预措施如何主要通过对抗衰老过程本身的关键分子机制来预防心血管疾病。总之，本综述旨在提供有价值的见解，以说明理解这些相互关联的过程如何能够指导开发针对日益增多的、患有令人担忧的肥胖问题的老年人群的新型有效心血管疗法。
