神经氨酸酶对感染单纯疱疹病毒的兔角膜细胞上Fc和C3b受体的影响。

Effect of neuraminidase on Fc and C3b receptors on rabbit corneal cells infected with herpes simplex virus.

作者信息

Hatano H, Oh J O

出版信息

Curr Eye Res. 1987 Jan;6(1):53-7. doi: 10.3109/02713688709020068.

DOI:10.3109/02713688709020068

Abstract

The effect of neuraminidase on Fc receptors (FcR) and C3b receptors (C3bR) was studied in epithelial, stromal and endothelial cells of the rabbit cornea infected with type 1 (HSV-1) and type 2 herpes simplex virus (HSV-2) in vitro. FcR were induced on epithelial, stromal and endothelial cells of the rabbit cornea by both HSV-1 and HSV-2, but their activities were not enhanced by neuraminidase. On the other hand, the treatment of HSV-infected corneal cells with neuraminidase resulted in the enhancement of C3bR activities on epithelial, stromal and endothelial cells infected with HSV-1, and the enhancing effect of neuraminidase was more pronounced on corneal endothelial cells. A similar neuraminidase treatment had no significant effect on C3bR activities on the corneal cells infected with HSV-2.

摘要

在体外，研究了神经氨酸酶对感染1型单纯疱疹病毒（HSV - 1）和2型单纯疱疹病毒（HSV - 2）的兔角膜上皮细胞、基质细胞和内皮细胞中Fc受体（FcR）和C3b受体（C3bR）的影响。HSV - 1和HSV - 2均可诱导兔角膜上皮细胞、基质细胞和内皮细胞产生FcR，但其活性未被神经氨酸酶增强。另一方面，用神经氨酸酶处理感染HSV的角膜细胞，可增强感染HSV - 1的上皮细胞、基质细胞和内皮细胞上C3bR的活性，且神经氨酸酶对角膜内皮细胞的增强作用更明显。类似的神经氨酸酶处理对感染HSV - 2的角膜细胞上C3bR的活性无显著影响。