根据帕金森病患者的体重指数，胆固醇水平对认知的影响存在差异。

Differential effects of cholesterol levels on cognition according to body mass index in Parkinson's disease.

机构信息

Department of Neurology, Inje University Sanggye Paik Hospital, Seoul, South Korea.

Department of Neurology, Yonsei University College of Medicine, 50 Yonsei-Ro, Seodaemun-Gu, Seoul, 03722, South Korea.

出版信息

Alzheimers Res Ther. 2024 Jan 31;16(1):24. doi: 10.1186/s13195-023-01326-2.

DOI:10.1186/s13195-023-01326-2

PMID:38297344

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10829366/

Abstract

BACKGROUND

Cholesterol is an essential component of the neuronal cell membrane and is crucial for neuronal function; however, the role of cholesterol levels in Parkinson's disease (PD) is debatable. This study investigated the complex relationship between total cholesterol (TC) levels, body mass index (BMI), and cognition in patients with PD.

METHODS

This study included 321 drug-naïve patients with PD who underwent dopamine transporter (DAT) imaging and baseline neuropsychological tests. Multivariate linear regression and Cox regression models were used to investigate the effect of TC levels on the composite score of each cognitive domain and dementia conversion after adjusting for covariates, respectively. Interaction analyses were performed to examine the interaction effect between TC levels and BMI on baseline cognition and dementia conversion.

RESULTS

TC levels and cognition showed no significant relationship after adjusting for potential confounders. A significant interaction effect between TC levels and BMI was observed in frontal/executive function and dementia conversion. Further analyses showed that TC levels were positively associated with frontal/executive function in the under-/normal weight group (β = 0.205, p = 0.013), whereas a negative relationship existed between TC levels and frontal/executive function in the obese group (β = - 0.213, p = 0.017). Cox regression analyses also showed the differential effects of TC levels on dementia conversion according to BMI (under-/normal weight group: hazard ratio [HR] = 0.550, p = 0.013; obese group: HR = 2.085, p = 0.014).

CONCLUSIONS

This study suggests a cross-over interaction between TC levels and BMI on cognitive symptoms in PD.

摘要

背景

胆固醇是神经元细胞膜的重要组成部分，对神经元功能至关重要；然而，胆固醇水平在帕金森病（PD）中的作用仍存在争议。本研究旨在探讨 PD 患者总胆固醇（TC）水平、体重指数（BMI）与认知之间的复杂关系。

方法

本研究纳入了 321 例未经药物治疗的 PD 患者，这些患者接受了多巴胺转运体（DAT）成像和基线神经心理学测试。使用多元线性回归和 Cox 回归模型，分别在调整协变量后，研究 TC 水平对每个认知域的综合评分和痴呆转化的影响。同时进行交互分析，以检验 TC 水平和 BMI 之间的交互效应对基线认知和痴呆转化的影响。

结果

在调整潜在混杂因素后，TC 水平与认知之间无显著相关性。TC 水平和 BMI 之间存在显著的交互作用，这种交互作用体现在额/执行功能和痴呆转化方面。进一步分析表明，TC 水平与额/执行功能在低体重/正常体重组呈正相关（β=0.205，p=0.013），而在肥胖组呈负相关（β= −0.213，p=0.017）。Cox 回归分析还显示，TC 水平对痴呆转化的影响根据 BMI 而有所不同（低体重/正常体重组：风险比 [HR]=0.550，p=0.013；肥胖组：HR=2.085，p=0.014）。