Abteilung Neuropädiatrie, Department of Pediatrics, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Department of Pediatrics, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Chem Senses. 2024 Jan 1;49. doi: 10.1093/chemse/bjae003.
In this study, the transfer of odorants, namely vanilla, and garlic, into the amniotic fluid (AF) during the second trimester was investigated by examination of collected AF samples through healthy adults. Eleven AF samples were collected from pregnant women (aged 32.9 ± 4.9 yr, 16-25 wk of gestation) undergoing diagnostic amniocentesis after eating garlic oil or vanilla powder in high-fat yogurt. The control group did not receive food before amniocentesis. Two vanilla, 3 garlic, and 6 control samples were collected through amniocentesis 60-120 min after ingestion. Samples were collected at -80 °C and carefully defrosted over 12 h at the same time point. Sixteen healthy volunteers (8 males, aged 26.5 ± 5.0 yr) were asked to judge AF samples with potential garlic or vanilla odors from controls in a 2-alternative forced choice (2AFC) paradigm. Judges were able to identify vanilla in the AF samples with an estimated probability of 50%, resulting in a significant P-value of < 0.001. In contrast, the identification of garlic was unsuccessful with a P-value of 0.86, and only 2 judges were able to identify both vanilla and garlic. According to the results of this study, the vanilla odor probably passes into the amniotic fluid.
在这项研究中，通过对食用大蒜油或香草粉后接受诊断性羊膜穿刺术的孕妇（年龄 32.9±4.9 岁，妊娠 16-25 周）收集的羊水（AF）样本进行检查，研究了气味剂（即香草和大蒜）在妊娠中期向羊水中的转移。对照组在羊膜穿刺术前未进食。在摄入后 60-120 分钟，通过羊膜穿刺术采集了 2 个香草、3 个大蒜和 6 个对照样本。样本在-80°C 下收集，并在同一时间点小心解冻 12 小时。16 名健康志愿者（8 名男性，年龄 26.5±5.0 岁）被要求在 2 种选择强制选择（2AFC）范式中从对照样本中判断具有潜在大蒜或香草气味的 AF 样本。评判者能够以 50%的估计概率识别 AF 样本中的香草，这导致 P 值显著<0.001。相比之下，大蒜的识别不成功，P 值为 0.86，只有 2 位评判者能够识别香草和大蒜。根据这项研究的结果，香草的气味可能会进入羊水。
