Department of Biomedical Sciences and Pathobiology, Virgnia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, United States.
Biomedical Sciences, Edward Via College of Osteopathic Medicine, Blacksburg, VA, United States.
Front Immunol. 2024 Jan 17;14:1330500. doi: 10.3389/fimmu.2023.1330500. eCollection 2023.
Systemic lupus erythematosus (SLE) is a systemic chronic disease initiated by an abnormal immune response to self and can affect multiple organs. SLE is characterized by the production of autoantibodies and the deposition of immune complexes. In regard to the clinical observations assessed by rheumatologists, several chemokines and cytokines also contribute to disease progression. One such chemokine and adhesion molecule is CXCL1 (otherwise known as fractalkine). CXCL1 is involved in cell trafficking and inflammation through recognition by its receptor, CXCR1. The CXCL1 protein consists of a chemokine domain and a mucin-like stalk that allows it to function both as a chemoattractant and as an adhesion molecule. In inflammation and specifically lupus, the literature displays contradictory evidence for the functions of CXCL1/CXCR1 interactions. In addition, the gut microbiota has been shown to play an important role in the pathogenesis of SLE. This review highlights current studies that illustrate the interactions of the gut microbiota and CXCR1 in SLE.
系统性红斑狼疮 (SLE) 是一种由针对自身的异常免疫反应引发的系统性慢性疾病，可影响多个器官。SLE 的特征是产生自身抗体和免疫复合物的沉积。就风湿病学家评估的临床观察而言，几种趋化因子和细胞因子也有助于疾病的进展。趋化因子和黏附分子之一是 CXCL1（也称为 fractalkine）。CXCL1 通过其受体 CXCR1 的识别参与细胞迁移和炎症。CXCL1 蛋白由趋化因子结构域和粘蛋白样茎组成，使其既能作为趋化因子又能作为黏附分子发挥作用。在炎症，特别是狼疮中，文献显示 CXCL1/CXCR1 相互作用的功能存在矛盾的证据。此外，肠道微生物群已被证明在 SLE 的发病机制中发挥重要作用。这篇综述强调了目前的研究，这些研究说明了肠道微生物群和 CXCR1 在 SLE 中的相互作用。
