Yang Wenjing, Hu Yifan, Cui Shufang
Laboratory Animal Science Department, Basic Medical School, Naval Medical University, Shanghai, China.
Changhai Hospital, Naval Medical University, Shanghai, China.
Aging Dis. 2024 Jan 11;16(1):137-45. doi: 10.14336/AD.2024.0109.
Health and longevity are the dreams of mankind and the main field of the medical community. The naked mole rat (NMR) is a unique murine animal with extremely long lives (exceeding 38 years), revealing little signs of aging such as reproductive decline, neural degenerative diseases, and cancer. They provide us with valuable perspectives on preventing age-related diseases. This review systematically summarized the characters of different systems of naked mole rats in aging resistance, and furtherly exploited the mechanisms for aging resistance form genome, telomeres, protein recycling, metabolism, and oxidative stress attitudes. As a species with a high similarity with human beings, it cannot be ruled out that after reasonable validity, safety and ethical evaluation, the dominant genes of naked mole rats will be developed in medical transformation, to realize the dream of human health and longevity.
健康与长寿是人类的梦想，也是医学界的主要领域。裸鼹鼠是一种独特的鼠类动物，寿命极长（超过38岁），几乎没有衰老迹象，如生殖能力下降、神经退行性疾病和癌症。它们为我们预防与年龄相关的疾病提供了宝贵的视角。本综述系统总结了裸鼹鼠不同系统在抗衰老方面的特征，并进一步从基因组、端粒、蛋白质循环、代谢和氧化应激等方面探讨了抗衰老机制。作为与人类高度相似的物种，不能排除在经过合理的有效性、安全性和伦理评估后，裸鼹鼠的优势基因将被开发用于医学转化，以实现人类健康长寿的梦想。
