Cooper R L, Goldman J M, Rehnberg G L
Environ Health Perspect. 1986 Dec;70:177-84. doi: 10.1289/ehp.8670177.
Appropriate regulation of reproductive processes are dependent upon the integrity of pituitary function. In this selected review, we evaluate the evidence that certain environmental compounds exert their effect on reproductive function via a direct action on the pituitary gland. We also discuss examples of changes in pituitary hormone secretion that occur in response to changes in neuronal or gonadal control of the pituitary. A limited number of studies suggest that measures of pituitary hormone secretion provide an early and sensitive measure of a compound's potential effects on the reproductive system. However, the most striking aspect of this area is the sparse and inconsistent information describing pituitary function following exposure to environmental pollutants.
生殖过程的适当调节依赖于垂体功能的完整性。在这篇选定的综述中，我们评估了某些环境化合物通过对垂体的直接作用影响生殖功能的证据。我们还讨论了因垂体的神经或性腺控制变化而发生的垂体激素分泌变化的例子。少数研究表明，垂体激素分泌的测量为化合物对生殖系统潜在影响提供了早期且敏感的指标。然而，该领域最显著的方面是，关于接触环境污染物后垂体功能的描述信息稀少且不一致。
