Department of Pathophysiology, West China College of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu 610041, China.
Department of Neurology, Neurological Diseases and Brain Function Laboratory, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
J Neuroimmunol. 2024 Mar 15;388:578290. doi: 10.1016/j.jneuroim.2024.578290. Epub 2024 Jan 12.
Recent studies have revealed the link between immune activation and neurodegenerative diseases.
By employing meta-analysis, we estimated the standardized mean difference (SMD) and their corresponding 95% confidence intervals (CIs) between the groups.
According to the pre-set criteria, a total of 21 published articles including 2377 ALS patients and 1244 HCs, as well as 60 articles including 5111 PD patients and 4237 HCs, were identified. This study provided evidence of peripheral immune activation in the pathogenesis of ALS and PD.
Our results suggested monitoring changes in peripheral blood immune cell populations, particularly lymphocyte subsets, will benefit understanding the developments and exploring reliable and specific biomarkers of these two diseases.
最近的研究揭示了免疫激活与神经退行性疾病之间的联系。
通过荟萃分析，我们估计了组间标准化均数差（SMD）及其相应的 95%置信区间（CI）。
根据预设标准，共确定了 21 篇已发表的文章，其中包括 2377 名 ALS 患者和 1244 名 HC，以及 60 篇文章，包括 5111 名 PD 患者和 4237 名 HC。本研究提供了外周免疫激活在 ALS 和 PD 发病机制中的证据。
我们的研究结果表明，监测外周血免疫细胞群，特别是淋巴细胞亚群的变化，将有助于了解这两种疾病的发展，并探索可靠和特异的生物标志物。
