Department of Internal Medicine, Bakirkoy Dr. Sadi Konuk Training & Research Hospital, University of Health Sciences, Istanbul, Turkey.
Department of Radiology, Bakirkoy Dr. Sadi Konuk Training & Research Hospital, University of Health Sciences, Istanbul, Turkey.
Acta Clin Croat. 2023 Apr;62(1):201-207. doi: 10.20471/acc.2023.62.01.23.
Mammography is one of the gold standard screening tests for breast cancer. The effects of mammography procedure on blood parameters are not known. This study aimed to investigate whether the procedure-associated breast compression affects the widely and simultaneously performed blood measurements of C-reactive protein (CRP), carcinoembryonic antigen (CEA), and cancer antigen (CA) 15-3. According to breast ultrasound examination results, participants were divided into 3 groups as follows: group 1 (participants with breast mass size ≥20.0 mm, n=48); group 2 (participants with breast mass size <20.0 mm, n=17); and group 3 (participants with no breast mass, n=23). In groups 1 and 2, on the day of the mammographic imaging study, serum CRP, CEA, and CA 15-3 levels were measured before and after the imaging study. Participants in group 3 had their blood parameters measured without mammography and/or any breast compression. Post-mammography blood measurements displayed a significant increase in serum CRP levels, and a significant decrease in serum CEA and CA 15-3 levels in group 1 (in comparison with the same day pre-mammography blood sampling levels; p<0.05 all). Although pre-mammography serum CEA levels in group 1 participants were significantly higher than those in group 2 and 3 participants, this significant elevation became nonsignificant at post-mammography measurements (p<0.05 and p>0.05, respectively). On the day of the mammographic imaging study, the optimal time of blood sampling for testing CRP, CEA and CA 15-3 levels in persons with a breast mass is before, but not after the mammographic imaging procedure. This issue requires additional detailed studies.
乳腺 X 线摄影是乳腺癌的金标准筛查试验之一。目前尚不清楚乳腺 X 线摄影程序对血液参数的影响。本研究旨在探讨与程序相关的乳房压迫是否会影响广泛且同时进行的 C 反应蛋白 (CRP)、癌胚抗原 (CEA) 和癌症抗原 (CA) 15-3 的血液测量。根据乳腺超声检查结果，将参与者分为 3 组：第 1 组 (乳房肿块大小≥20.0mm 的参与者，n=48)；第 2 组 (乳房肿块大小<20.0mm 的参与者，n=17)；第 3 组 (无乳房肿块的参与者，n=23)。在第 1 组和第 2 组中，在乳腺 X 线摄影成像研究当天，在成像研究前后测量血清 CRP、CEA 和 CA 15-3 水平。第 3 组参与者在没有乳腺 X 线摄影和/或任何乳房压迫的情况下测量其血液参数。与同日乳腺 X 线摄影前采血水平相比，乳腺 X 线摄影后第 1 组的血清 CRP 水平显著升高，血清 CEA 和 CA 15-3 水平显著降低 (p<0.05 均)。尽管第 1 组参与者的乳腺 X 线摄影前血清 CEA 水平明显高于第 2 组和第 3 组参与者，但在乳腺 X 线摄影后测量时，这种显著升高变得不显著 (p<0.05 和 p>0.05，分别)。在乳腺 X 线摄影成像研究当天，对于有乳房肿块的人，检测 CRP、CEA 和 CA 15-3 水平的最佳采血时间是在乳腺 X 线摄影成像程序之前，而不是之后。这个问题需要进一步的详细研究。
