Fu Yijie, Li Hui
School of Medicine and Nursing, Chengdu University, Chengdu, Sichuan, China (mainland).
Med Sci Monit. 2016 Sep 6;22:3154-62. doi: 10.12659/msm.896563.
BACKGROUND Breast cancer is the most common malignant cancer in women worldwide. The tumor markers Cancer Antigen 15-3 (CA15-3) and Carcinoembryonic Antigen (CEA) are frequently used for screening and monitoring breast cancer. MATERIAL AND METHODS We conducted a meta-analysis of 13 published case-control studies to assess the associations between serum levels of CA15-3 and CEA with breast cancer susceptibility, including 1179 cases and 493 controls. The analyses were performed on malignant tumor and benign tumor, as well as in different subgroups with respect to the patient ethnicities and clinical tumor stages. RESULTS This systematic review and meta-analysis of association studies shows that serum levels of CA15-3 and CEA are potential biomarkers for breast cancer monitoring. When stratified by clinical stage, we noticed that although malignant tumors in all stages show elevated levels of CA15-3, it is greatly associated with the tumor stage, as it increases as breast tumor stage worsens. CONCLUSIONS This study clarifies the inconsistent conclusions from multiple studies, and provides a precise estimation for clinical utility of 2 important biomarkers, CA15-3 and CEA, in breast cancer monitoring. Thus, our study will shed lights on the prognosis of breast cancer patients.
背景 乳腺癌是全球女性中最常见的恶性肿瘤。肿瘤标志物癌抗原15-3（CA15-3）和癌胚抗原（CEA）常用于乳腺癌的筛查和监测。材料与方法 我们对13项已发表的病例对照研究进行了荟萃分析，以评估血清CA15-3和CEA水平与乳腺癌易感性之间的关联，包括1179例病例和493例对照。分析在恶性肿瘤和良性肿瘤以及不同种族和临床肿瘤分期的亚组中进行。结果 这项关联研究的系统评价和荟萃分析表明，血清CA15-3和CEA水平是乳腺癌监测的潜在生物标志物。按临床分期分层时，我们注意到尽管所有阶段的恶性肿瘤CA15-3水平均升高，但它与肿瘤分期密切相关，随着乳腺肿瘤分期的恶化而升高。结论 本研究阐明了多项研究中不一致结论，并对CA15-3和CEA这两种重要生物标志物在乳腺癌监测中的临床应用提供了精确估计。因此，我们的研究将为乳腺癌患者的预后提供线索。
