Verbruggen Stefaan W
Centre for Predictive in vitro Models and Centre for Bioengineering, School of Engineering and Materials Science, Queen Mary University of London, London E1 4NS, United Kingdom.
Digital Environment Research Institute, Queen Mary University of London, United Kingdom.
J Bone Oncol. 2024 Jan 17;44:100526. doi: 10.1016/j.jbo.2024.100526. eCollection 2024 Feb.
Metastatic bone disease is a complex condition resulting from the migration and colonization of cancer cells from their primary site to the bone microenvironment, where they typically develop a metastatic niche. Osteocytes, the most abundant cells in bone tissue and the master regulators of bone remodelling, are increasingly thought to play a crucial role in this process through intricate interactions with cancer cells. This review covers the recent progress made in exploring the multifaceted interactions between osteocytes and cancer cells in the metastatic microenvironment, highlighting the importance of signalling networks in bone metastases. Though these interactions are particularly complex, the renewed focus of researchers on osteocytes within the last 5 years has uncovered multiple new potential molecular mechanisms underlying osteocyte-mediated regulation of cancer cell survival, proliferation, and invasion. A number of key papers will be discussed in detail, emphasizing the significance of signalling pathways and molecular crosstalk, and exploring potential therapeutic strategies targeting osteocyte-cancer cell interactions to improve patient treatment and outcomes.
转移性骨病是一种复杂的病症，由癌细胞从其原发部位迁移并定植到骨微环境中所致，在该微环境中癌细胞通常会形成转移龛。骨细胞是骨组织中数量最多的细胞，也是骨重塑的主要调节因子，人们越来越认为它通过与癌细胞的复杂相互作用在这一过程中发挥关键作用。本综述涵盖了在探索转移性微环境中骨细胞与癌细胞之间多方面相互作用方面取得的最新进展，突出了信号网络在骨转移中的重要性。尽管这些相互作用特别复杂，但研究人员在过去5年里对骨细胞的重新关注揭示了骨细胞介导的癌细胞存活、增殖和侵袭调控背后的多种新的潜在分子机制。将详细讨论一些关键论文，强调信号通路和分子串扰的重要性，并探索针对骨细胞-癌细胞相互作用的潜在治疗策略，以改善患者的治疗和预后。
