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母乳和婴儿配方奶喂养的早产儿中外泌体微小RNA的特征分析。

Characterization of exosomal microRNAs in preterm infants fed with breast milk and infant formula.

作者信息

Kim Eun-Bit, Song Jun Hwan, Le Linh Nguy-Hoang, Kim Ho, Koh Ji Won, Seo Yekyeng, Jeong Hwal Rim, Kim Hyun-Taek, Ryu Seongho

机构信息

Soonchunhyang Institute of Med-bio Science (SIMS), Soonchunhyang University, Cheonan, Republic of Korea.

Soonchunhyang University Cheonan Hospital, College of Medicine, Soon-chunhyang University, Cheonan, Republic of Korea.

出版信息

Front Nutr. 2024 Jan 18;11:1339919. doi: 10.3389/fnut.2024.1339919. eCollection 2024.

DOI:10.3389/fnut.2024.1339919
PMID:38304545
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10830786/
Abstract

Breastfeeding not only reduces infection-related morbidity, but also increases growth of preterm infants. Advantages of breast milk (BM) for preterm infants are significant. They continue to be studied. However, because not all preterm infants can receive breastfeeding, bovine-based infant formula (IF) is used as an alternative, which may increase the risk of several preterm complications. Exosomes isolated from biofluids are emerging as biomarkers in research of various diseases. Here, we characterized miRNA contents of exosomes in urine and serum samples of preterm infants who were BM and IF fed and performed transcriptomic analysis of small RNA libraries. We identified significantly up-regulated 6 miRNAs and 10 miRNAs, respectively. Gene Ontology (GO) analysis revealed that target genes of these miRNAs might participate in neuronal development, immunity modulation, detoxification of reactive oxygen species, and transmembrane exchange. Our data suggest that exosome-based systemic screening for preterm infants with breastfeeding might be a screening tool for identifying target molecules involved in therapy for preterm infants in neonatal intensive care unit (NICU) and for future application as nutraceutical formulations or pharmaceuticals.

摘要

母乳喂养不仅能降低与感染相关的发病率，还能促进早产儿生长。母乳对早产儿的益处显著，仍在持续研究中。然而，由于并非所有早产儿都能接受母乳喂养，以牛乳为基础的婴儿配方奶粉（IF）被用作替代品，这可能会增加多种早产并发症的风险。从生物流体中分离出的外泌体正作为各种疾病研究中的生物标志物出现。在此，我们对接受母乳喂养和配方奶粉喂养的早产儿尿液和血清样本中的外泌体miRNA含量进行了表征，并对小RNA文库进行了转录组分析。我们分别鉴定出6种和10种显著上调的miRNA。基因本体（GO）分析显示，这些miRNA的靶基因可能参与神经发育、免疫调节、活性氧解毒和跨膜交换。我们的数据表明，基于外泌体的对母乳喂养早产儿的系统筛查可能是一种筛查工具，用于识别新生儿重症监护病房（NICU）中参与早产儿治疗的靶分子，并在未来用作营养制剂或药物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11ab/10830786/11733bd039fa/fnut-11-1339919-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11ab/10830786/a3f91f113d33/fnut-11-1339919-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11ab/10830786/4bb1cf168e9d/fnut-11-1339919-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11ab/10830786/86eed1cff371/fnut-11-1339919-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11ab/10830786/afaea506147c/fnut-11-1339919-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11ab/10830786/11733bd039fa/fnut-11-1339919-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11ab/10830786/a3f91f113d33/fnut-11-1339919-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11ab/10830786/4bb1cf168e9d/fnut-11-1339919-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11ab/10830786/86eed1cff371/fnut-11-1339919-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11ab/10830786/afaea506147c/fnut-11-1339919-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11ab/10830786/11733bd039fa/fnut-11-1339919-g005.jpg

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Deciphering the role of precursor miR-12136 and miR-8485 in the progression of intellectual disability (ID).解析前体miR-12136和miR-8485在智力障碍（ID）进展中的作用。
IBRO Neurosci Rep. 2022 Oct 21;13:393-401. doi: 10.1016/j.ibneur.2022.10.005. eCollection 2022 Dec.
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MicroRNA miR-627-5p restrains pulmonary artery smooth muscle cell dysfunction by targeting MAP 2 K4 and PI3K/AKT signaling.微小RNA miR-627-5p通过靶向MAP 2 K4和PI3K/AKT信号通路抑制肺动脉平滑肌细胞功能障碍。
Genes Environ. 2022 Sep 27;44(1):23. doi: 10.1186/s41021-022-00251-4.
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MicroRNA-4516 in Urinary Exosomes as a Biomarker of Premature Ovarian Insufficiency.尿液外泌体中的 microRNA-4516 作为卵巢早衰的生物标志物。
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