Ordiway George, McDonnell Miranda, Sanchez Jason Tait
Roxelyn and Richard Department of Communication Sciences and Disorders, Northwestern University, Evanston, IL, USA.
Central Auditory Physiology Laboratory, Northwestern University, Evanston, IL, USA.
Neurosci Insights. 2024 Jan 30;19:26331055241228308. doi: 10.1177/26331055241228308. eCollection 2024.
The auditory brainstem response (ABR) is important for both clinical and basic auditory research. It is a non-invasive measure of hearing function with millisecond-level precision. The ABR can not only measure the synchrony, speed, and efficacy of auditory physiology but also detect different modalities of hearing pathology and hearing loss. ABRs are easily acquired in vertebrate animal models like reptiles, birds, and mammals, and complement existing molecular, developmental, and systems-level research. One such model system is the chicken; an excellent animal for studying auditory development, structure, and function. However, the ABR for chickens was last reported nearly 4 decades ago. The current study examines how decades of ABR characterization in other animal species support findings from the chicken ABR. We replicated and expanded on previous research using 43 chicken hatchlings 1- and 2-day post-hatch. We report that click-evoked chicken ABRs presented with a peak waveform morphology, amplitude, and latency like previous avian studies. Tone-evoked ABRs were found for frequencies from 250 to 4000 Hertz (Hz) and exhibited a range of best sensitivity between 750 and 2000 Hz. Objective click-evoked and tone-evoked ABR thresholds were comparable to subjective thresholds. With these revisited measurements, the chicken ABR still proves to be an excellent example of precocious avian development that complements decades of molecular, neuronal, and systems-level research in the same model organism.
听觉脑干反应（ABR）在临床和基础听觉研究中都很重要。它是一种具有毫秒级精度的听力功能非侵入性测量方法。ABR不仅可以测量听觉生理的同步性、速度和功效，还能检测不同类型的听力病理学和听力损失。在爬行动物、鸟类和哺乳动物等脊椎动物模型中很容易获得ABR，它可以补充现有的分子、发育和系统水平的研究。鸡就是这样一种模型系统，是研究听觉发育、结构和功能的优秀动物。然而，鸡的ABR研究上一次报道是在近40年前。本研究探讨了数十年来在其他动物物种中进行的ABR特征研究如何支持鸡ABR的研究结果。我们对43只孵化后1天和2天的雏鸡重复并扩展了先前的研究。我们报告说，短声诱发的鸡ABR呈现出与先前鸟类研究相似的峰值波形形态、幅度和潜伏期。发现了250至4000赫兹（Hz）频率的纯音诱发ABR，其最佳灵敏度范围在750至2000 Hz之间。客观的短声诱发和纯音诱发ABR阈值与主观阈值相当。通过这些重新测量，鸡ABR仍然被证明是早熟鸟类发育的一个优秀例子，它补充了在同一模式生物中进行的数十年分子、神经元和系统水平的研究。
