Nopparat Junya, Sujipuli Kawee, Ratanasut Kumrop, Weerawatanakorn Monthana, Prasarnpun Surisak, Thongbai Bussagon, Laothaworn Walailak, Inthima Phithak
Office of the Dean, Faculty of Science and Health Technology, Navamindradhiraj University, 3, White Road, Vajira Hospital, Dusit, Bangkok, 10300, Thailand.
Center of Agricultural Biotechnology, Naresuan University, 99 Moo 9, Tha Pho, Phitsanulok, 65000, Thailand.
Heliyon. 2024 Jan 17;10(2):e24509. doi: 10.1016/j.heliyon.2024.e24509. eCollection 2024 Jan 30.
Brahmi ( (L.) Wettst.) is extensively used as a nutritional supplement in various commercial products as the plant contains abundant phytochemicals and has antioxidant properties. This study assessed the phytochemical contents, antioxidant properties, and DNA damage protection among seven Brahmi products sold through Thai online markets. Results showed that the P6 sample exhibited 3.5-7.5 fold higher bacoside contents than values observed in the other six product samples. The P6 sample also demonstrated the highest TTC, TFC, and TPC compared to the other brands. For antioxidant activity, the samples (P1-P7) displayed high capacity to scavenge DPPH free radicals with slightly significant differences ranging from 78.37 ± 0.25 to 87.21 ± 0.05 at -value ≤0.01. The P6 sample showed strong protection against HO-induced oxidation of DNA strand breakage, indicating highly potent phytochemical compounds with effective free radical scavenging activity, and the ability to prevent DNA damage. The P6 sample showed promise as a valuable ingredient for the development of functional food products. However, further in vivo animal and clinical studies are required to explore the neuroprotective enhancement effects of Brahmi extracts.
假马齿苋（Brahmi ( (L.) Wettst.)）作为一种营养补充剂被广泛应用于各种商业产品中，因为该植物含有丰富的植物化学物质且具有抗氧化特性。本研究评估了通过泰国在线市场销售的七种假马齿苋产品的植物化学成分、抗氧化特性以及对DNA损伤的保护作用。结果显示，P6样品中的总苷含量比其他六种产品样品中的含量高3.5至7.5倍。与其他品牌相比，P6样品还表现出最高的总三萜含量、总黄酮含量和总酚含量。对于抗氧化活性，样品（P1 - P7）表现出较高的清除DPPH自由基的能力，在p值≤0.01时，清除率范围为78.37±0.25至87.21±0.05，差异略有显著性。P6样品对羟基自由基诱导的DNA链断裂氧化具有很强的保护作用，表明其具有高效的植物化学化合物，具有有效的自由基清除活性以及防止DNA损伤的能力。P6样品有望成为功能性食品开发的宝贵成分。然而，需要进一步进行体内动物和临床研究，以探索假马齿苋提取物的神经保护增强作用。
