Age-Related Inflammation and Degeneration Research Unit, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, 10330, Thailand.
Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, 10330, Thailand.
Sci Rep. 2021 Jan 12;11(1):596. doi: 10.1038/s41598-020-80045-2.
Bacopa monnieri (Linn.) Wettst. has been used in traditional medicine as a drug to enhance and improve memory. In this regard, this study aims to provide B. monnieri's efficacy as a neuroprotective drug and as a nootropic against various neurological diseases. Literatures were collected, following Prisma guidelines, from databases, including Scopus, PubMed, Google Scholar, and Science Direct and were scrutinized using a quality scoring system. Means, standard deviations and 'n' numbers were extracted from the metrics and analyzed. Jamovi computer software for Mac was used to carry out the meta-analysis. The selected studies suggested that the plant extracts were able to show some improvements in healthy subjects which were determined in Auditory Verbal Learning Task, digit span-reverse test, inspection time task and working memory, even though it was not significant, as no two studies found statistically significant changes in the same two tests. B. monnieri was able to express modest improvements in subjects with memory loss, wherein only a few of the neuropsychological tests showed statistical significance. B. monnieri in a cocktail with other plant extracts were able to significantly reduce the effects of Alzheimer's disease, and depression which cannot be solely credited as the effect of B. monnieri. Although in one study B. monnieri was able to potentiate the beneficial effects of citalopram; on the whole, currently, there are only limited studies to establish the memory-enhancing and neuroprotective effects of B. monnieri. More studies have to be done in the future by comparing the effect with standard drugs, in order to establish these effects clinically in the plant and corroborate the preclinical data.
印度蔊菜（Linn.） Wettst. 已在传统医学中被用作增强和改善记忆力的药物。在这方面，本研究旨在提供印度蔊菜作为神经保护药物和益智药对抗各种神经疾病的功效。根据 Prisma 指南，从包括 Scopus、PubMed、Google Scholar 和 Science Direct 在内的数据库中收集文献，并使用质量评分系统进行仔细审查。从指标中提取均值、标准差和 'n' 数量，并进行分析。使用 Mac 版的 Jamovi 计算机软件进行荟萃分析。所选研究表明，植物提取物能够在健康受试者中显示出一些改善，这些改善在听觉言语学习任务、数字跨度反转测试、检查时间任务和工作记忆中得到了确定，尽管这并不显著，因为没有两项研究在相同的两项测试中发现统计学上的显著变化。印度蔊菜能够在记忆丧失的受试者中表达适度的改善，其中只有少数神经心理学测试显示出统计学意义。印度蔊菜与其他植物提取物的混合物能够显著降低阿尔茨海默病和抑郁症的影响，这不能仅仅归功于印度蔊菜的作用。尽管在一项研究中，印度蔊菜能够增强西酞普兰的有益作用；但总的来说，目前只有有限的研究能够确定印度蔊菜的增强记忆力和神经保护作用。为了在植物中临床确立这些作用并证实临床前数据，未来还需要进行更多的研究，将其效果与标准药物进行比较。
