Zhu Li, Li Hui, Chen Yizhu, Dai Yongjing, Li Xiru
Senior Department of General Surgery, The First Medical Center of PLA General Hospital, Beijing, China.
Senior Department of Vascular Surgery, The First Medical Center of PLA General Hospital, Beijing, China.
Ann Transl Med. 2024 Feb 1;12(1):4. doi: 10.21037/atm-22-6538. Epub 2023 Oct 27.
Inguinal hernia repair is a routine surgical procedure and many methods are being applied to improve the operation. In this study, an abdominal wall defect model was established in New Zealand rabbits. The safety and efficacy of the test product was evaluated by observing the physiological state and clinical manifestations and conducting anatomical observations in the rabbits after use of the nano-silver-poly-DL-lactide-co-caprolactone-small intestinal submucosa (NS-PLCL-SIS) mesh.
A total of 18 New Zealand rabbits were randomly divided into a test group and a blank group. Routine blood and serum biochemical tests, and anatomical observations were conducted on postoperative day 30 (D30), day 60 (D60), and day 90 (D90). During the study period, all animals underwent clinical observation, and the obtained data were counted.
The results showed that the NS-PLCL-SIS mesh was degraded within 90 days, and there was no abnormal reaction and no animal death during the test. There was no significant difference in the changes of animal body weight at each time point. There was no infectious inflammatory reaction in the wound at the study site, and the ocular wound healed well 7 days after the operation.
Under the conditions of this experiment, the NS-PLCL-SIS mesh had good performance in the repair of abdominal wall defect in New Zealand rabbits and is clinically safe for veterinarians.
腹股沟疝修补术是一种常规外科手术，目前应用了多种方法来改进该手术。在本研究中，在新西兰兔身上建立了腹壁缺损模型。通过观察纳米银-聚-DL-丙交酯-共-己内酯-小肠黏膜下层（NS-PLCL-SIS）补片使用后兔的生理状态、临床表现并进行解剖观察，评估受试产品的安全性和有效性。
将18只新西兰兔随机分为试验组和空白组。在术后第30天（D30）、第60天（D60）和第90天（D90）进行常规血液和血清生化检测以及解剖观察。在研究期间，对所有动物进行临床观察，并对获得的数据进行统计。
结果显示，NS-PLCL-SIS补片在90天内降解，试验期间未出现异常反应，也无动物死亡。各时间点动物体重变化无显著差异。研究部位伤口无感染性炎症反应，术后7天眼部伤口愈合良好。
在本实验条件下，NS-PLCL-SIS补片在新西兰兔腹壁缺损修复中表现良好，对兽医临床来说是安全的。
