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2012-2022 年维多利亚州基于医院的堕胎和门诊早期药物流产数量变化:一项回顾性队列研究。

Changes in the numbers of hospital-based abortions and outpatient early medical abortions in Victoria, 2012-22: a retrospective cohort study.

机构信息

Melbourne Medical School, the University of Melbourne, Melbourne, VIC.

Murdoch Children's Research Institute, Melbourne, VIC.

出版信息

Med J Aust. 2024 Feb 19;220(3):145-153. doi: 10.5694/mja2.52203. Epub 2024 Feb 2.

Abstract

OBJECTIVES

To assess changes in the monthly numbers of hospital-based abortions and outpatient early medical abortions in Victoria during January 2012 - March 2022, with a particular interest in the impact of the coronavirus disease 2019 (COVID-19) pandemic.

STUDY DESIGN

Population-based retrospective cohort study; time series analysis of Victorian Admitted Episodes Dataset (VAED) and Pharmaceutical Benefits Scheme (PBS) data.

SETTING, PARTICIPANTS: All admitted care episodes in Victoria during 1 January 2012 - 31 March 2022 with medical abortion as the principal diagnosis; all PBS claims for mifepristone-misoprostol (MS-2 Step) during 1 January 2015 (date of listing) - 31 March 2022.

MAIN OUTCOME MEASURES

Changes in monthly numbers (with 95% confidence intervals [CIs]) of admissions for hospital-based and outpatient early medical abortions during the pre-pandemic period (January 2012 - March 2020), the first full month of the COVID-19 pandemic (April 2020), and the pandemic period (May 2020 - March 2022).

RESULTS

The monthly number of hospital-based abortions declined in Victoria during the pre-pandemic period (slope, -2.92 [95% CI, -3.45 to -2.38] per month); the rate of decline was greater during the pandemic period (slope, -5.74 [95% CI, -10.5 to -0.96] per month). The monthly number of outpatient early medical abortions increased during the pre-pandemic period (slope, 5.94 [95% CI, 5.34-6.34] per month); it declined during the first month of the pandemic (slope, -26.4 [95% CI, -70.1 to -17.3] per month), but did not significantly change thereafter. The total monthly number of abortions during the pandemic period did not deviate markedly from the pre-pandemic median value. The pre-pandemic declines in monthly numbers of abortions in major city hospitals, in private hospitals, or at earlier than 14 weeks' gestation intensified during the pandemic period. During January 2015 - March 2020, 14 634 of 103 496 abortions were outpatient medical abortions (14%); during the pandemic period, 11 154 of 33 056 abortions were outpatient medical abortions (33%).

CONCLUSIONS

The use of outpatient early medical abortion has steadily increased in Victoria since the PBS listing of mifepristone-misoprostol, which helped ensure access to abortion during the COVID-19 pandemic. Outpatient medical abortions may eventually outnumber surgical early abortions in Victoria, but they are not always appropriate: hospitals will continue to be essential for comprehensive abortion care.

摘要

目的

评估 2012 年 1 月至 2022 年 3 月期间维多利亚州医院堕胎和门诊早期药物流产的每月数量变化,特别关注 2019 年冠状病毒病(COVID-19)大流行的影响。

研究设计

基于人群的回顾性队列研究;维多利亚州住院病例数据集(VAED)和药品福利计划(PBS)数据的时间序列分析。

地点、参与者:2012 年 1 月至 2022 年 3 月期间,维多利亚州所有以医疗流产为主要诊断的住院治疗病例;2015 年 1 月(上市日期)至 2022 年 3 月期间,所有 PBS 对米非司酮-米索前列醇(MS-2 步)的索赔。

主要观察指标

大流行前时期(2012 年 1 月至 2020 年 3 月)、COVID-19 大流行的第一个整月(2020 年 4 月)和大流行期间(2020 年 5 月至 2022 年 3 月)每月医院和门诊早期药物流产数量(95%置信区间[CI])的变化。

结果

在大流行前时期,维多利亚州的医院堕胎数量逐月减少(斜率,每月减少 2.92 [95%CI,3.45 至 2.38]);大流行期间的下降速度更快(斜率,每月减少 5.74 [95%CI,10.5 至 0.96])。在大流行前时期,门诊早期药物流产的数量逐月增加(斜率,每月增加 5.94 [95%CI,5.34-6.34]);在大流行的第一个月下降(斜率,每月减少 26.4 [95%CI,70.1 至-17.3]),但此后没有明显变化。大流行期间的总堕胎数量与大流行前的中位数没有明显差异。大流行期间,主要城市医院、私立医院或 14 周妊娠前堕胎数量逐月减少的情况有所加剧。2015 年 1 月至 2020 年 3 月期间,103496 例堕胎中有 14634 例为门诊药物流产(14%);大流行期间,33056 例堕胎中有 11154 例为门诊药物流产(33%)。

结论

自米非司酮-米索前列醇列入 PBS 以来,维多利亚州门诊早期药物流产的使用稳步增加,这有助于确保在 COVID-19 大流行期间获得堕胎服务。门诊药物流产最终可能超过维多利亚州的手术早期堕胎,但并非总是如此:医院仍将是全面堕胎护理的重要场所。

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