Department of Surgery, Yokohama City University, Yokohama, Japan;
Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan.
Anticancer Res. 2024 Feb;44(2):815-822. doi: 10.21873/anticanres.16873.
BACKGROUND/AIM: Perioperative inflammation and the nutritional status affect both short- and long-term oncological outcomes in various malignancies. We clarified the clinical impacts of the CRP-albumin-lymphocyte (CALLY) index in patients with esophageal cancer who received curative treatment.
The present study included 180 patients who underwent curative treatment for esophageal cancer between 2005 and 2020. The prognosis and clinicopathological parameters were compared between a high-fibrinogen group and a low-fibrinogen group.
The 3- and 5-year overall survival rates were 50.0% and 42.6%, respectively, in the CALLY index-low group, and 75.9% and 66.6% in the CALLY index-high group. The differences between the two groups were statistically significant (p<0.001). Univariate and multivariate analyses demonstrated that the CALLY index was an independent prognostic factor [hazard ratio=2.310, 95% confidence interval=1.416-3.767, p<0.001]. Similar results were observed in recurrence-free survival. When comparing the details of postoperative surgical complications, there was a significant difference in the incidence of anastomotic leakage. The incidence of anastomotic leakage was 40.2% in the CALLY index-low group, while it was 27.5% in the CALLY index-high group (p=0.030).
The pretreatment CALLY index is one of the independent prognostic factors for esophageal cancer. The CALLY index might become a promising biomarker for the treatment and management of esophageal cancer.
背景/目的：围手术期炎症和营养状况会影响各种恶性肿瘤的短期和长期肿瘤学结果。我们明确了接受根治性治疗的食管癌患者中 CRP-白蛋白-淋巴细胞（CALLY）指数的临床影响。
本研究纳入了 180 例于 2005 年至 2020 年间接受根治性食管癌治疗的患者。对高纤维蛋白原组和低纤维蛋白原组的预后和临床病理参数进行了比较。
CALLY 指数低组的 3 年和 5 年总生存率分别为 50.0%和 42.6%，CALLY 指数高组分别为 75.9%和 66.6%。两组之间的差异具有统计学意义（p<0.001）。单因素和多因素分析表明，CALLY 指数是一个独立的预后因素[风险比=2.310，95%置信区间=1.416-3.767，p<0.001]。无复发生存率也观察到了类似的结果。在比较术后手术并发症的详细情况时，吻合口漏的发生率存在显著差异。CALLY 指数低组的吻合口漏发生率为 40.2%，CALLY 指数高组的发生率为 27.5%（p=0.030）。
治疗前的 CALLY 指数是食管癌的独立预后因素之一。CALLY 指数可能成为食管癌治疗和管理的有前途的生物标志物。
