Division of Rheumatology, Department of Medicine, University of Colorado Anschutz Medical Center, Aurora, CO, USA.
Best Pract Res Clin Rheumatol. 2024 May;38(2):101930. doi: 10.1016/j.berh.2024.101930. Epub 2024 Feb 1.
CD8 T cells expressing granzyme K are enriched in synovial tissue from patients with rheumatoid arthritis and in tissues affected by several other autoimmune diseases. The roles these cells play in autoimmune disease is under active investigation, and several recent studies have begun to shed light on this question. Putting this cell type into functional perspective is especially important given their enrichment at the sites of disease. This review summarizes available evidence for the presence of CD8 T cells and other granzyme K-expressing cells in tissues in autoimmune diseases and discusses the effects these cells may have on the pathogenesis of autoimmune conditions.
表达颗粒酶 K 的 CD8 T 细胞在类风湿关节炎患者的滑膜组织中以及在受几种其他自身免疫性疾病影响的组织中富集。这些细胞在自身免疫性疾病中的作用正在积极研究中，最近的几项研究开始阐明这个问题。鉴于它们在疾病部位的富集，将这种细胞类型置于功能视角下尤为重要。这篇综述总结了在自身免疫性疾病组织中存在 CD8 T 细胞和其他表达颗粒酶 K 的细胞的现有证据，并讨论了这些细胞可能对自身免疫条件的发病机制产生的影响。
