Department of Internal Medicine and Oncology, Faculty of Medicine, Semmelweis University, Budapest, Hungary.
Faculty of Medicine, Department of Pathology and Cancer Research, Semmelweis University, Budapest, Hungary.
J Med Case Rep. 2024 Feb 3;18(1):41. doi: 10.1186/s13256-023-04338-6.
The kidney biopsy is a routine procedure. Once an indication has been established, the benefit-risk balance may be considered. Sometimes, even with effective treatment, a severe complication may develop.
We present the case of a Caucasian 20-year-old young woman admitted to investigating and treating acute kidney injury. Renal involvement was characterized by kidney damage requiring hemodialysis treatment, positive immunologic testing, 0.5 g/day proteinuria, and microscopic hematuria. Contraindications were excluded, so an ultrasound-guided kidney biopsy was performed. To reduce the bleeding complication, Octostim (desmopressin) was administered. There were no direct complications following the kidney biopsy, so we continued the immunosuppressive treatment. Histologically founded thrombotic microangiopathy. However, 1 week later, severe bleeding developed with the need for urgent surgical left kidney removal.
Kidney biopsy can be considered a routine procedure, and various bleeding episodes are most common in terms of complications, the detection of which is essential. Delayed bleeding complications are rare and can be caused by minor injuries. Our young patient had no injury during the hospitalization. We hypothesized that the developed serious and delayed bleeding complication resulted from effective immunosuppressive treatment. To the best of our knowledge, this is the first such case to date. However, renal biopsy in the case of thrombotic microangiopathy requires caution.
肾脏活检是一种常规操作。一旦确定了适应证,就可以考虑其获益-风险平衡。有时,即使进行了有效的治疗,也可能会出现严重的并发症。
我们报告了一例 20 岁的白人年轻女性,因急性肾损伤接受检查和治疗。肾脏受累的特征是需要血液透析治疗的肾脏损伤、免疫检测阳性、每天 0.5 克蛋白尿和镜下血尿。排除了禁忌证,因此进行了超声引导下的肾脏活检。为了减少出血并发症,给予了 Octostim(去氨加压素)。肾脏活检后没有直接并发症,因此我们继续进行免疫抑制治疗。组织学发现血栓性微血管病。然而,1 周后,出现严重出血,需要紧急手术切除左肾。
肾脏活检可以被认为是一种常规操作,出血是最常见的并发症,必须检测到这些并发症。迟发性出血并发症很少见,可能是由轻微损伤引起的。我们的年轻患者在住院期间没有受伤。我们推测,严重和迟发性出血并发症是有效的免疫抑制治疗引起的。据我们所知,这是迄今为止首例此类病例。然而,对于血栓性微血管病患者,肾脏活检需要谨慎。