Ji Jiazhong, Li Zhaoyang, Xue Long, Xue Huaming, Wen Tao, Yang Tao, Ma Tong, Tu Yihui
Department of Orthopaedics, Yangpu Hospital, School of Medicine, Tongji University, Shanghai, 200090, China.
Endocrine. 2024 Jul;85(1):279-286. doi: 10.1007/s12020-024-03712-8. Epub 2024 Feb 3.
Osteoporosis has been a widespread concern for older women, especially postmenopausal women. Thyroid function is crucial for bone metabolism. However, the relationship between thyroid function variation within thyroxine reference range and bone mineral density (BMD) remains ambiguous. The objective of this study was to evaluate the effect of subclinical hypothyroidism or hyperthyroidism on total spinal BMD in postmenopausal women.
Based on data from the National Health and Nutrition Examination Survey (NHANES) 2007-2010, multivariable weighted logistic regression was used to evaluate the relationships between total spine BMD and TSH among postmenopausal women aged ≥50.
After accounting for a number of variables, this study discovered that the middle TSH tertile was associated with a decreased probability of osteoporosis. Additionally, the subgroup analysis revealed that postmenopausal women over the age of 65 or people with an overweight BMI had a clearer relationship between total spine BMD and TSH.
The total spinal BMD had a positive relationship with thyroid stimulating hormone in postmenopausal women, and that appropriate TSH level (1.38-2.32 mIU/L) was accompanied by higher total spinal BMD.
骨质疏松症一直是老年女性尤其是绝经后女性广泛关注的问题。甲状腺功能对骨代谢至关重要。然而，甲状腺功能在甲状腺素参考范围内的变化与骨密度（BMD）之间的关系仍不明确。本研究的目的是评估亚临床甲状腺功能减退或亢进对绝经后女性全脊柱骨密度的影响。
基于2007 - 2010年美国国家健康与营养检查调查（NHANES）的数据，采用多变量加权逻辑回归评估50岁及以上绝经后女性全脊柱骨密度与促甲状腺激素（TSH）之间的关系。
在考虑了多个变量后，本研究发现TSH处于中间三分位数与骨质疏松症概率降低相关。此外，亚组分析显示，65岁以上的绝经后女性或体重指数超重的人群中，全脊柱骨密度与TSH之间的关系更为明显。
绝经后女性全脊柱骨密度与促甲状腺激素呈正相关，适当的TSH水平（1.38 - 2.32 mIU/L）伴随着更高的全脊柱骨密度。
