Fünfgeld E W, Kulhanek F
Arzneimittelforschung. 1978;28(9):1489-91.
19 chronic schizophrenics who had previously been resistant to various neuroleptic treatment regimens, were given extemely high doses (ca. 300-500 mg daily) of fluphenazine. 2 infusions were given in the morning and in the afternoon. Therapy results, possible side effects and the transition to oral and i.m. (depot) modes of application are discussed. The above-mentioned extemely high doses of fluphenazine appear to be contra-indicated in depressive states and in cases of latent organic brain changes. Psychiatric state hospitals would be able to carry out this form of treatment in a special unit for "intensive care" in connection with appropriate social rehabilitative methods.
19名先前对各种抗精神病药物治疗方案耐药的慢性精神分裂症患者,接受了极高剂量(约每日300 - 500毫克)的氟奋乃静。上午和下午各进行一次输注。讨论了治疗结果、可能的副作用以及向口服和肌内注射(长效)给药方式的转换。上述极高剂量的氟奋乃静似乎在抑郁状态和潜在器质性脑病变的情况下是禁忌的。精神病医院能够在一个与适当社会康复方法相结合的“重症监护”特殊单元中开展这种治疗形式。