Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Trends Biotechnol. 2024 Jul;42(7):929-937. doi: 10.1016/j.tibtech.2024.01.002. Epub 2024 Feb 2.
As more is learned about the benefits of microbes, their potential to prevent and treat disease is expanding. Microbial therapeutics are less burdensome and costly to produce than traditional molecular drugs, often with superior efficacy. Yet, as with most medicines, controlled dosing and delivery to the area of need remain key challenges for microbes. Advances in materials to control small-molecule delivery are expected to translate to microbes, enabling similar control with equivalent benefits. In this perspective, recent advances in living biotherapeutics are discussed within the context of new methods for their controlled release. The integration of these advances provides a roadmap for the design, synthesis, and analysis of controlled microbial therapeutic delivery systems.
随着人们对微生物益处的了解不断增加，它们预防和治疗疾病的潜力也在不断扩大。微生物疗法在生产上比传统的分子药物负担更小、成本更低，而且通常具有更好的疗效。然而，与大多数药物一样，控制剂量和将药物输送到需要的区域仍然是微生物面临的关键挑战。控制小分子输送的材料方面的进展有望转化为微生物领域，使微生物也能获得类似的控制效果和益处。在这篇观点文章中，我们将讨论在控制微生物释放的新方法的背景下，活体生物治疗剂的最新进展。这些进展的整合为设计、合成和分析控制微生物治疗性药物输送系统提供了路线图。
