Translational Research in Pain Program, Department of Clinical Sciences, College of Veterinary Medicine, Comparative Pain Research and Education Centre, North Carolina State University, Raleigh, NC, USA.
Department of Statistics, North Carolina State University, Raleigh, NC, USA.
Sci Rep. 2024 Feb 3;14(1):2827. doi: 10.1038/s41598-024-52324-9.
This study aimed to determine the prevalence of osteoarthritis (OA) and associated clinical signs in young dogs. Owners of dogs aged 8 months-4 years from a single practice, were contacted in random order, to participate in a general health screen. Clinical and orthopedic examinations were performed. Each joint was scored for pain reactions (0-4). Orthogonal radiographs of all joints were made under sedation. Each joint was scored for radiographic OA (rOA) severity on an 11-point scale. Clinical OA (cOA) was defined as an overlap of rOA and joint pain in ≥ 1 joint. Owners completed OA questionnaires. The owners of 123 dogs agreed to participate. Overall, 39.8% (49/123) of dogs had rOA in ≥ 1 joint, and 16.3% (20/123) or 23.6% (29/123) dogs had cOA, depending on the cut-off value of joint pain; moderate (2), or mild (1), respectively. Owners of dogs with cOA observed signs of impairment in approximately 30% of cases. Only 2 dogs with cOA were receiving OA pain management. The most commonly affected joints in descending order of frequency were elbow, hip, tarsus, and stifle. Radiographically visible OA is common in young dogs, and 40-60% of dogs with rOA had cOA. However, OA-pain appears underdiagnosed and undertreated in young dogs.
本研究旨在确定年轻犬中骨关节炎（OA）的流行率及其相关临床体征。随机联系了一家诊所的 8 月龄至 4 岁犬的主人，邀请他们参加一般健康筛查。进行了临床和骨科检查。每个关节的疼痛反应（0-4 分）进行评分。所有关节均在镇静下进行正交放射照相。每个关节的放射照相 OA（rOA）严重程度评分为 11 分制。临床 OA（cOA）定义为 rOA 和≥1 个关节的关节疼痛重叠。主人完成了 OA 问卷。123 只狗的主人中有 123 只同意参与。总体而言，49/123（39.8%）只狗在≥1 个关节存在 rOA，20/123（16.3%）或 29/123（23.6%）只狗存在 cOA，具体取决于关节疼痛的截止值；分别为中度（2）或轻度（1）。约 30%的 cOA 犬主人观察到了功能障碍的迹象。仅 2 只患有 cOA 的狗接受了 OA 疼痛管理。最常受影响的关节按频率降序排列为肘、髋、跗关节和膝关节。放射照相可见的 OA 在年轻犬中很常见，rOA 犬中有 40-60%存在 cOA。然而，OA 疼痛在年轻犬中被低估和治疗不足。
