Katoch K, Ramu G, Ramanathan U
Indian J Lepr. 1985 Jul-Sep;57(3):499-506.
Different regimens containing Rifampicin have been tried in treating paucibacillary leprosy patients. In our study we have studied three regimens. Regimen I consists of treating patients with Rifampicin 600 mg once a month for six months combined with Dapsone 100mg daily and treatment is stopped at six months. Regimen II is same as regimen I except that instead of stopping treatment at the end of six months the treatment was continued with dapsone 100 mg daily for another six months and treatment was stopped at one year. Regimen III is the same as recommended by I.A.L. in which treatment is started with Rifampicin 600 mg daily for seven days in the first month to be followed by Rifampicin 600 mg once a month for five more months. This is combined with dapsone 100mg daily for one year. Treatment in this group is also stopped at one year. Eighty one patients in Regimen I, thirty five patients in Regimen II and sixty three patients in Regimen III completed the six month treatment. It was found that the inactivation index in all the three regimens was nearly the same.
已尝试使用含利福平的不同治疗方案治疗少菌型麻风患者。在我们的研究中，我们研究了三种治疗方案。方案I包括每月一次给予患者600毫克利福平，持续六个月，同时每日给予100毫克氨苯砜，六个月后停止治疗。方案II与方案I相同，只是在六个月结束时不停止治疗，而是继续每日给予100毫克氨苯砜，再持续六个月，一年后停止治疗。方案III与国际麻风防治协会（I.A.L.）推荐的方案相同，即第一个月每日给予600毫克利福平，持续七天，随后再连续五个月每月一次给予600毫克利福平。这与每日100毫克氨苯砜联合使用一年。该组治疗也在一年后停止。方案I中的81名患者、方案II中的35名患者和方案III中的63名患者完成了六个月的治疗。结果发现，所有三种治疗方案的灭活指数几乎相同。
