高压氧治疗作为麻风病多药联合治疗的辅助手段
THERAPEUTIC HYPERBARIC OXYGENATION AS AN ADJUNCT TO MULTIDRUG THERAPY IN HANSEN'S DISEASE.
作者信息
DE Sylva Plk, Nangpal S, John M J, Shah K M, Bhattacharya S, Mani H, Hukkoo A K, Saxena C
机构信息
Classified Specialist in Dermatology, Leprology and STD, Department of Dermatology, Leprology & STD, INHS Sanjivani, Willingdon Island, Naval Base, Kochi 682 004.
Classified Specialist in Marine Medicine and Officer-in-Charge, INHS ASVINI, Colaba, Mumbai-400 005.
出版信息
Med J Armed Forces India. 1999 Apr;55(2):98-103. doi: 10.1016/S0377-1237(17)30260-5. Epub 2017 Jun 26.
Hansen's disease is a chronic infection caused by . Current therapy for this disease is with the WHO recommended Multi Drug Therapy (MDT) with DDS, rifampicin and clofazimine. Hyper Baric Oxygen Therapy (HBOT) has been used to treat many medical conditions including infections with a great deal of success. It's efficacy on various species of mycobacteria and other bacteria have been studied in vitro and in vivo and it is found to be an effective antimicrobial agent under specified conditions. HBOT has been used to treat Hansen's disease, including drug resistant lepromatous leprosy cases with good results. However there is a paucity of literature on this form of therapy. We have treated twenty cases of Hansen's disease with HBOT prior to exhibiting MDT as per the WHO schedule. There has been a marked regression in skin signs especially decrease in erythema and flattening of raised lesions. This correlated well with the histopathological picture which showed a reduction in the inflammatory exudate.
麻风病是一种由……引起的慢性感染。目前针对这种疾病的治疗方法是采用世界卫生组织推荐的由氨苯砜、利福平及氯法齐明组成的联合化疗方案（MDT）。高压氧疗法（HBOT）已被用于治疗包括感染在内的多种病症，并取得了很大成功。其对各种分枝杆菌和其他细菌的疗效已在体外和体内进行了研究，发现在特定条件下它是一种有效的抗菌剂。HBOT已被用于治疗麻风病，包括耐药性瘤型麻风病例，效果良好。然而，关于这种治疗方式的文献很少。我们按照世界卫生组织的时间表，在开展MDT之前，先用HBOT治疗了20例麻风病患者。皮肤症状有明显消退，尤其是红斑减少，凸起病变变平。这与组织病理学图像密切相关，后者显示炎症渗出物减少。
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