Al-Windy Salah
Department of Biology, College of Science, Baghdad University, Baghdad, Iraq.
J Med Life. 2023 Oct;16(10):1448-1451. doi: 10.25122/jml-2023-0027.
Typhoid fever (TF) is a systemic infection caused by transmitted through contaminated water, food, or contact with infected individuals. In various infectious diseases, blood viscosity (BV) is affected by changes in hemoglobin concentrations and acute phase reactants. Inflammatory responses can lead to elevated plasma protein levels and further affect BV. This study aimed to investigate BV changes in patients with acute TF. A cross-sectional study was performed involving 55 patients with acute TF compared to 38 healthy controls. BV and inflammatory parameters were measured in both groups. TF patients showed reduced blood cells compared to healthy controls (p=0.001). Additionally, plasma total protein (TP) levels significantly increased to 10.79±1.05 g/L in TF patients compared to 7.035±1.44 g/L in healthy controls (p=0.03). Hematocrit (HCT) levels were 11.67±2.89% in TF patients and 12.84±2.02% in healthy controls (p=0.07), suggesting a trend towards increased BV in TF patients. Elevated BV is involved in the pathogenesis of different inflammatory and infectious diseases. The increased BV in TF patients may raise the risk of complications. Therefore, monitoring BV might be a crucial tool in TF patients, mainly in the high-risk group, for early detection of cardiovascular complications.
伤寒热（TF）是一种由通过受污染的水、食物或与感染者接触传播的病原体引起的全身性感染。在各种传染病中，血液粘度（BV）受血红蛋白浓度和急性期反应物变化的影响。炎症反应可导致血浆蛋白水平升高并进一步影响BV。本研究旨在调查急性TF患者的BV变化。进行了一项横断面研究，纳入了55例急性TF患者，并与38例健康对照进行比较。对两组患者测量了BV和炎症参数。与健康对照相比，TF患者的血细胞减少（p = 0.001）。此外，TF患者的血浆总蛋白（TP）水平显著升高至10.79±1.05 g/L，而健康对照为7.035±1.44 g/L（p = 0.03）。TF患者的血细胞比容（HCT）水平为11.67±2.89%，健康对照为12.84±2.02%（p = 0.07），提示TF患者有BV升高的趋势。BV升高与不同炎症和传染病的发病机制有关。TF患者BV升高可能会增加并发症的风险。因此，监测BV可能是TF患者（主要是高危组）早期发现心血管并发症的关键工具。
