Department of Family Physician (CCFP), Madigan Medical Centre, Calgary, Alberta, Canada.
Department of Pharmacology, College of Medicine, University of Baghdad, Baghdad, Iraq.
J Med Life. 2022 Dec;15(12):1458-1463. doi: 10.25122/jml-2022-0167.
Myopathy is a disease characterized by muscle dysfunction in general and may be associated with genetics, medication such as statins, or inflammation. In 2019, an epidemic viral infection (SARS-CoV-2 virus) that invaded most countries worldwide appeared and caused acute respiratory disease. Consequently, patients had to take a group of drugs for a relatively long treatment period. According to several studies, there was an increase in the cases of muscular disorders due to several factors. This study aimed to (1) investigate the relationship between COVID-19 and myopathy and (2) identify the causes and prevention methods. A systematic review was conducted, analyzing several articles from the following databases: ResearchGate, Medline, DOAJ (The Directory of Open-Access Journals), PubMed, and Google Scholar. After performing the search and filtering the results, we included 61 articles. There was a strong relationship between COVID-19 and myopathy, especially in patients admitted to the ICU department, due to medication or neurological dysregulation with multiorgan dysfunctions such as polyneuropathy, peripheral nerve involvement, dysautonomia, Guillain-Barré syndrome, and many others.
肌病是一种以肌肉功能障碍为特征的疾病，可能与遗传、他汀类药物等药物或炎症有关。2019 年，一种侵袭世界大多数国家的流行病毒（SARS-CoV-2 病毒）出现，导致急性呼吸道疾病。因此，患者需要服用一组药物进行相对较长的治疗期。根据几项研究，由于多种因素，肌肉疾病的病例有所增加。本研究旨在 (1) 研究 COVID-19 与肌病之间的关系，(2) 确定病因和预防方法。进行了系统评价，分析了来自以下数据库的几篇文章：ResearchGate、Medline、DOAJ（开放获取期刊目录）、PubMed 和 Google Scholar。在进行搜索和过滤结果后，我们纳入了 61 篇文章。COVID-19 与肌病之间存在很强的关系，特别是在因药物或神经调节紊乱导致多器官功能障碍（如多发性神经病、周围神经受累、自主神经功能障碍、吉兰-巴雷综合征等）而入住 ICU 病房的患者中。
