Takeuchi M, Fujitani K, Kurogane K, Bai H T, Toda C, Yamasaki T, Takano S, Fukuzaki H
Jpn Circ J. 1985 Dec;49(12):1225-34. doi: 10.1253/jcj.49.1225.
To make a comparison of two exponential models of the time constant (Tw: Weiss's method, Tc: exponential analysis with a variable asymptote) during left ventricular (LV) isovolumic relaxation, we assessed LV pressure decay in 104 patients with coronary artery disease (CADpts) and 21 normal subjects at rest and after pacing, and investigated the hemodynamic determinants of these two models using forward-backward stepwise multiple regression analysis. At rest, Tw was prolonged as the left ventricular minimal pressure (LVPmin), the left ventricular end-diastolic pressure (LVEDP) and the end-systolic volume (ESV) increased (multiple regression coefficient: R = 0.87), whereas Tc was prolonged as ESV and regional wall motion abnormality (RWMA) increased (R = 0.72). Pacing-induced changes in Tw were augmented as LVPmin and RWMA increased (R = 0.75), whereas changes in Tc were augmented as RWMA increased (R = 0.63). Thus, the changes in Tw may be due to an increase in LVPmin rather than to any direct effect of ischemia on the relaxation rate. The relaxation rate can be evaluated more reliably by Tc than by Tw, irrespective of associated pressure changes during ischemia in CADpts.
为比较左心室等容舒张期时间常数的两种指数模型（Tw：魏斯法，Tc：可变渐近线指数分析），我们评估了104例冠心病患者（CAD患者）和21名正常受试者静息及起搏后的左心室压力衰减情况，并采用前后向逐步多元回归分析研究了这两种模型的血流动力学决定因素。静息时，Tw随左心室最小压力（LVPmin）、左心室舒张末期压力（LVEDP）和收缩末期容积（ESV）增加而延长（多元回归系数：R = 0.87），而Tc随ESV和局部室壁运动异常（RWMA）增加而延长（R = 0.72）。起搏引起的Tw变化随LVPmin和RWMA增加而增大（R = 0.75），而Tc的变化随RWMA增加而增大（R = 0.63）。因此，Tw的变化可能是由于LVPmin增加，而非缺血对舒张速率的任何直接影响。无论CAD患者缺血期间相关压力变化如何，通过Tc比通过Tw能更可靠地评估舒张速率。
