Dye Alexander, Stein Rachel, Lewis Gregory, Hew Karina
Obstetrics and Gynecology, University of Florida College of Medicine - Jacksonville, Jacksonville, USA.
Radiology, University of Florida College of Medicine - Jacksonville, Jacksonville, USA.
Cureus. 2024 Jan 2;16(1):e51556. doi: 10.7759/cureus.51556. eCollection 2024 Jan.
Leptomeningeal carcinomatosis (LMC) is an extremely rare site for metastasis from a primary ovarian cancer. LMC occurs when the thin layers of tissue that surround the brain and spinal cord are infiltrated by ovarian cancer metastasis. We present a case of a 63-year-old female with recurrent metastatic mucinous adenocarcinoma of the ovary who was diagnosed with LMC. While undergoing sixth-line chemotherapy, she presented with debilitating headaches and gait instability. Brain MRI revealed subarachnoid enhancement and other findings diagnostic of LMC. Given the rarity of this disease, treatment protocols have yet to be established. In patients with primary ovarian cancer that present with new onset neurological complaints, LMC should be suspected and appropriate imaging obtained.
软脑膜癌病（LMC）是原发性卵巢癌转移的极其罕见部位。当围绕脑和脊髓的薄层组织被卵巢癌转移浸润时，就会发生软脑膜癌病。我们报告一例63岁女性，患有复发性转移性卵巢黏液腺癌，被诊断为软脑膜癌病。在接受第六线化疗时，她出现了使人衰弱的头痛和步态不稳。脑部磁共振成像（MRI）显示蛛网膜下腔强化及其他诊断软脑膜癌病的表现。鉴于这种疾病的罕见性，治疗方案尚未确立。对于出现新发神经症状的原发性卵巢癌患者，应怀疑软脑膜癌病并进行适当的影像学检查。
