Agrawal Meenakshi G, Kanungo Himanshu, Gupta Mukesh, Mishra Kratika, Soni Akansha, Agrawal Navneet
Orthodontics and Dentofacial Orthopaedics, Index Institute of Dental Sciences, Indore, IND.
Paedodontics, Index Institute of Dental Sciences, Indore, IND.
Cureus. 2024 Jan 4;16(1):e51669. doi: 10.7759/cureus.51669. eCollection 2024 Jan.
Pain relief is an integral component of any orthodontic procedure given its high association with patient compliance and treatment adherence. A transdermal drug delivery system (TDDS) is a non-invasive method of drug delivery through the skin surface that can spread the medication throughout the dermis at a predetermined rate to produce a local or systemic effect. It might be used in place of hypodermic injections and the oral medication route. A transdermal analgesic, often known as a pain reliever patch, is an adhesive patch that contains medication to treat mild-to-severe pain. Many opioids and non-steroidal anti-inflammatory drugs are currently available as patches. TDDS offers many benefits over the conventional medication delivery method. The non-invasive transdermal route or therapy has features such as excellent bioavailability, stable medication plasma concentration, and no first-pass metabolism effect. This review aims to explore the available evidence on the use of transdermal patches for pain relief in orthodontic procedures and possibly suggest recommendations based on the findings.
鉴于疼痛缓解与患者依从性和治疗坚持性高度相关，它是任何正畸治疗不可或缺的组成部分。透皮给药系统（TDDS）是一种通过皮肤表面进行非侵入性给药的方法，它可以以预定速率将药物扩散到整个真皮层，以产生局部或全身作用。它可以替代皮下注射和口服给药途径。透皮镇痛药，通常称为止痛贴，是一种含有治疗轻至重度疼痛药物的粘贴片。目前有许多阿片类药物和非甾体抗炎药以贴片形式供应。与传统给药方法相比，透皮给药系统有许多优点。非侵入性透皮途径或疗法具有生物利用度高、药物血浆浓度稳定且无首过代谢效应等特点。本综述旨在探讨有关在正畸治疗中使用透皮贴片缓解疼痛的现有证据，并可能根据研究结果提出建议。
