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苯乙烯/乙烯/丁烯共聚物和聚氨酯材质的输尿管双J支架植入前后的结壳情况

Encrustation of the ureteral double-J Stents made of styrene/ethylene/butylene and polyurethane before and after implantation.

作者信息

Haliński Adam, Pasik Kamila, Haliński Andrzej, Trinchieri Alberto, Buchholz Noor, Arkusz Katarzyna

机构信息

Department of Clinical Genetics and Pathology, University of Zielona Góra, Zielona Góra, Poland.

Department of Biomedical Engineering, University of Zielona Góra, Zielona Góra, Poland.

出版信息

Acta Bioeng Biomech. 2022;24(2):109-117.

Abstract

PURPOSE

The aim of this study was to determine the affinity to crystal, calculi and biofilm deposition on ureteral double-J stents (DJ stents) after ureterorenoscopic-lithotripsy procedure (URS-L). The analysis was performed in two aspects: to determine which material used for fabricating ureteral stents promotes encrustation and which part of the DJ stents is the most vulnerable for blockage.

METHODS

One hundred and twenty patients with an indwelling DJ stent duration between 7 and 78 days were included in this study. The encrustation of DJ stents was characterized by scanning electron microscopy (SEM), and the mechanical properties of DJ stents were examined using the standard MTS Micro Bionix tensile test.

RESULTS

This study showed that polyurethane catheters have a much higher affinity for encrustation than styrene/ethylene/butylene block copolymer. Obtained results indicated the proximal (renal pelvis) and distal (urinary bladder) part is the most susceptible to post-URS-L fragments and urea salt deposition. Both the DJ ureteral stents' outer and inner surfaces were completely covered even after 7 days of implantation.

CONCLUSIONS

Performed analysis pointed out that polyurethane DJ stents have a much higher affinity for encrustation of calculi and NaCl crystals compared to the silicone-based copolymer. The surface of the ureteral stents needs improvement to minimize salt and kidney stone deposition, causing pre-biofilm formation and the occurrence of defects and cracks.

摘要

目的

本研究旨在确定输尿管镜碎石术(URS-L)后输尿管双J支架(DJ支架)上晶体、结石和生物膜沉积的亲和力。分析从两个方面进行:确定用于制造输尿管支架的哪种材料会促进结壳,以及DJ支架的哪一部分最容易堵塞。

方法

本研究纳入了120例留置DJ支架7至78天的患者。通过扫描电子显微镜(SEM)对DJ支架的结壳情况进行表征,并使用标准的MTS Micro Bionix拉伸试验检测DJ支架的机械性能。

结果

本研究表明,聚氨酯导管比苯乙烯/乙烯/丁烯嵌段共聚物具有更高的结壳亲和力。所得结果表明,近端(肾盂)和远端(膀胱)部分最易受到URS-L术后碎片和尿素盐沉积的影响。即使在植入7天后,DJ输尿管支架的内外表面也完全被覆盖。

结论

进行的分析指出,与硅基共聚物相比,聚氨酯DJ支架对结石和氯化钠晶体结壳的亲和力要高得多。输尿管支架的表面需要改进,以尽量减少盐和肾结石的沉积,从而导致生物膜前体形成以及出现缺陷和裂缝。

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