Synthesis, bio-evaluation and molecular docking studies of thiadiazole-based Schiff base derivatives.

Recently, thiadiazole-containing drugs have gained greater clinical relevance and are being explored for the development of new antidiabetic, antiurease and antimicrobial agents that target drug resistance. The authors disclose the synthesis of -(5-[4-(trifluoromethyl)phenyl]-1,3,4-thiadiazol-2-yl)methanimine derivatives starting from 4-(trifluoromethyl)benzoic acid. All of the synthesized derivatives were evaluated for their biological potential in order to investigate the inhibitory activity against antidiabetic, antiurease and antibacterial profiles. Compounds , and showed excellent inhibitory activities due to the hydrogen bonding presence of -OH, -F and -CF substitutions attached with the phenyl ring. The present study provides potent antidiabetic, antiurease and antimicrobial agents that can be further optimized to discover novel antidiabetic, antiurease drugs.