Iwata M A, Iwata S
Jpn J Ophthalmol. 1985;29(4):460-7.
Physicochemical changes of the lens protein produced by UV light may be considered to be one of the pathogenic factors in the development of cataract. The effect of filters to eliminate these changes were investigated and evaluated using an in vitro system. UV irradiation caused degradation of alpha-crystallin to proteins with lower molecular weight, and thus the crystallin did not show insolubility. beta H- and beta L-crystallin showed insolubilization and aggregation with yellow coloration by photooxidation. The S-S linkage produced by oxidation of the SH group caused gamma-crystallin to aggregate and become insoluble. These chemical changes are prevented significantly by the UV-cutting colored filters.
紫外线导致的晶状体蛋白理化变化可能被视为白内障发生发展的致病因素之一。使用体外系统研究并评估了滤光片消除这些变化的效果。紫外线照射导致α-晶状体蛋白降解为分子量较低的蛋白质，因此晶状体蛋白未表现出不溶性。βH-和βL-晶状体蛋白通过光氧化表现出不溶性和聚集，并伴有黄色着色。SH基团氧化产生的S-S键导致γ-晶状体蛋白聚集并变得不溶。这些化学变化可被紫外线截止滤光片显著抑制。
