Langer G, Neumark J, Koinig G, Graf M, Schönbeck G
Neuropsychobiology. 1985;14(3):118-20. doi: 10.1159/000118216.
Treatment-refractory depressed patients who objected to electroconvulsive therapy (ECT) were given a series of anesthesias with isoflurane (Forane), a modern and established inhalation anesthetic. According to our hypothesis to be tested, the brief period of electrocerebral silence (ES), which can be observed shortly after the grand mal seizure in ECT, may be in itself a crucial biological determinant for the therapeutic effects of ECT. Isoflurane is the only drug known to effect an ES in the EEG in nontoxic concentrations, which does not result in adverse effects on any body organ including the brain; no seizure activity can be observed. Eleven depressed patients received a total of 36 anesthesias with isoflurane (ES narcotherapy). Rapid antidepressant effects were observed in 9 patients (p less than 0.0001). Effects were reproducible and lasted up to several weeks. No adverse effects of anesthesia were noticed.
那些反对接受电休克疗法（ECT）的难治性抑郁症患者接受了一系列异氟烷（福仑）麻醉，异氟烷是一种成熟的现代吸入麻醉剂。根据我们要检验的假设，在ECT的癫痫大发作后不久即可观察到的短暂脑电静息期（ES），其本身可能是ECT治疗效果的关键生物学决定因素。异氟烷是唯一已知在无毒浓度下可使脑电图出现脑电静息的药物，且对包括大脑在内的任何身体器官均无不良影响；未观察到癫痫发作活动。11名抑郁症患者共接受了36次异氟烷麻醉（脑电静息麻醉疗法）。9名患者观察到快速抗抑郁效果（p<0.0001）。效果具有可重复性，可持续数周。未发现麻醉的不良反应。
