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精准配方，这是基于对阳离子氨基酸转运体的研究而提出的一种改善膳食氨基酸吸收的新概念。

Precision formulation, a new concept to improve dietary amino acid absorption based on the study of cationic amino acid transporters.

作者信息

Morin Guillaume, Pinel Karine, Heraud Cécile, Le-Garrec Soizig, Wayman Chloé, Dias Karine, Terrier Frédéric, Lanuque Anthony, Fontagné-Dicharry Stéphanie, Seiliez Iban, Beaumatin Florian

机构信息

Université de Pau et des Pays de l'Adour, E2S UPPA, INRAE, NUMEA, Saint-Pée-sur-Nivelle, France.

出版信息

iScience. 2024 Jan 14;27(2):108894. doi: 10.1016/j.isci.2024.108894. eCollection 2024 Feb 16.

DOI:10.1016/j.isci.2024.108894
PMID:38318367
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10839688/
Abstract

Amino acid (AA) transporters (AAT) control AA cellular fluxes across membranes, contributing to maintain cellular homeostasis. In this study, we took advantage of rainbow trout metabolic feature, which highly relies on dietary AA, to explore the cellular and physiological consequences of unbalanced diets on AAT dysregulations with a particular focus on cationic AAs (CAA), frequently underrepresented in plant-based diets. Results evidenced that 24 different CAAT are expressed in various trout tissues, part of which being subjected to AA- and CAA-dependent regulations, with exchanger being prone to the strongest dysregulations. Moreover, CAA were shown to control two major AA-dependent activation pathways (namely mTOR and GCN2) but at different strength according to the CAA considered. A new feed formulation strategy has been put forward to improve specifically the CAA supplemented absorption in fish together with their growth performance. Such "precision formulation" strategy reveals high potential for nutrition practices, especially in aquaculture.

摘要

氨基酸（AA）转运体（AAT）控制着氨基酸跨膜的细胞通量，有助于维持细胞内稳态。在本研究中，我们利用虹鳟鱼高度依赖日粮氨基酸的代谢特征，探讨不均衡日粮对AAT失调的细胞和生理影响，特别关注植物性日粮中经常含量不足的阳离子氨基酸（CAA）。结果表明，24种不同的CAA转运体在虹鳟鱼的各种组织中表达，其中部分转运体受氨基酸和CAA依赖性调节，而交换体最容易出现失调。此外，CAA被证明可控制两条主要的氨基酸依赖性激活途径（即mTOR和GCN2），但根据所考虑的CAA不同，其控制强度也不同。我们提出了一种新的饲料配方策略，以特别提高鱼类对补充CAA的吸收及其生长性能。这种“精准配方”策略在营养实践中显示出巨大潜力，尤其是在水产养殖中。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a95e/10839688/e6180badaa43/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a95e/10839688/064f609e6d6c/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a95e/10839688/1116224b29ef/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a95e/10839688/ac9b2ebf1175/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a95e/10839688/25bd2698ba72/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a95e/10839688/91b1c5ddd1d4/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a95e/10839688/7eb3a6b1fc0d/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a95e/10839688/e6180badaa43/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a95e/10839688/064f609e6d6c/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a95e/10839688/1116224b29ef/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a95e/10839688/ac9b2ebf1175/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a95e/10839688/25bd2698ba72/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a95e/10839688/91b1c5ddd1d4/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a95e/10839688/7eb3a6b1fc0d/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a95e/10839688/e6180badaa43/gr7.jpg

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Physiol Rep. 2019 Nov;7(21):e14274. doi: 10.14814/phy2.14274.
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