mTOR 作为营养信号和细胞生长的中央枢纽。
mTOR as a central hub of nutrient signalling and cell growth.
机构信息
Department of Oral Biochemistry and Molecular Biology, School of Dentistry, Kyung Hee University, Seoul, Korea.
Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA.
出版信息
Nat Cell Biol. 2019 Jan;21(1):63-71. doi: 10.1038/s41556-018-0205-1. Epub 2019 Jan 2.
The highly conserved protein kinase mechanistic target of rapamycin (mTOR; originally known as mammalian target of rapamycin) is a central cell growth regulator connecting cellular metabolism and growth with a wide range of environmental inputs as part of mTOR complex 1 (mTORC1) and mTORC2. In this Review, we introduce the landmark discoveries in the mTOR field, starting from the isolation of rapamycin to the molecular characterizations of key components of the mTORC signalling network with an emphasis on amino acid sensing, and discuss the perspectives of mTORC inhibitors in therapeutic applications.
高度保守的蛋白激酶雷帕霉素靶蛋白（mTOR；最初称为哺乳动物雷帕霉素靶蛋白）是一种细胞生长调节剂的核心，将细胞代谢和生长与广泛的环境输入联系起来，作为 mTOR 复合物 1（mTORC1）和 mTORC2 的一部分。在这篇综述中，我们从雷帕霉素的分离开始，介绍 mTOR 领域的里程碑式发现，到 mTOR 信号网络关键成分的分子特征，重点讨论氨基酸感应，并讨论 mTORC 抑制剂在治疗应用中的前景。
Zotero 插件