硫唑嘌呤在新鲜人血中的代谢动力学
Kinetics of azathioprine metabolism in fresh human blood.
作者信息
Chrzanowska M, Hermann T, Gapińska M
出版信息
Pol J Pharmacol Pharm. 1985 Sep-Oct;37(5):701-8.
PMID:3832014
Abstract
Azathioprine (AZA) is transformed in the whole fresh human blood in vitro to 6-mercaptopurine (6-MP). The rate of the above reaction was followed as a function of time at 25, 30 and 37 degrees C. Pseudo-first-order rate constants and thermodynamic parameters were calculated. The statistical evaluation of the parameters calculated was provided. Half-life time of 6-MP formation in blood from AZA at e.g. 37 degrees C was equal to 28.9 +/- 2.8 min.
摘要
硫唑嘌呤（AZA）在新鲜全血中于体外转化为6-巯基嘌呤（6-MP）。在25、30和37摄氏度下，跟踪上述反应速率随时间的变化情况。计算了伪一级反应速率常数和热力学参数，并对所计算的参数进行了统计学评估。例如，在37摄氏度时，AZA在血液中形成6-MP的半衰期为28.9±2.8分钟。
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