Bluth R, Langnickel R, Ott T
Pol J Pharmacol Pharm. 1985 Nov-Dec;37(6):753-63.
The acetylcholine turnover rate and the enzymatic activity of choline acetyltransferase were determined in the nucleus accumbens and striatum. Whereas both apomorphine and a serotonin agonist MK 212 led to a decrease in acetylcholine turnover rate, haloperidol showed the opposite effect in the nucleus accumbens and striatum, respectively. Dopamine and serotonin agonists induced a depression of the enzymatic activity but this effect was less pronounced than the effect on acetylcholine turnover rate. It is concluded that in the nucleus accumbens and striatum the cholinergic interneurons appear to be modulated by dopaminergic and serotonergic systems in an inhibitory manner.
测定了伏隔核和纹状体中乙酰胆碱的周转率以及胆碱乙酰转移酶的酶活性。阿扑吗啡和5-羟色胺激动剂MK 212均导致乙酰胆碱周转率降低，而氟哌啶醇在伏隔核和纹状体中分别表现出相反的作用。多巴胺和5-羟色胺激动剂可诱导酶活性降低，但这种作用不如对乙酰胆碱周转率的影响明显。结论是，在伏隔核和纹状体中，胆碱能中间神经元似乎受到多巴胺能和5-羟色胺能系统的抑制性调节。
