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加拿大女性摄入的叶酸超过了可耐受最高摄入量,但在妊娠中期,很少有人达到膳食胆碱的推荐摄入量:来自 CHILD 队列研究的数据。

Women in Canada are consuming above the upper intake level of folic acid but few are meeting dietary choline recommendations in the second trimester of pregnancy: data from the CHILD cohort study.

机构信息

Department of Pediatrics, The University of British Columbia and BC Children's Hospital Research Institute, Vancouver, BC V5Z 4H4, Canada.

Department of Nutritional Sciences, University of Toronto, Toronto, ON M5T 3M7, Canada.

出版信息

Appl Physiol Nutr Metab. 2024 Jun 1;49(6):868-873. doi: 10.1139/apnm-2023-0258. Epub 2024 Feb 6.

DOI:10.1139/apnm-2023-0258
PMID:38320263
Abstract

There is concern that during a low-risk pregnancy, women are consuming more than recommended (400 µg/day) supplemental folic acid and may not meet recommendations for other nutrients. The objective of this study was to determine folic acid supplement use and dietary folate intakes in the second trimester (week 18) of pregnancy in women ( = 2996) in the Canadian CHILD cohort study. Vitamin B12 and choline intakes were also assessed because they are metabolically related to folate. The majority of participants (71.6%) were consuming a daily prenatal supplement. Twenty-eight percent of women ( = 847) reported consuming a folic acid supplement and of these women, 45.3% had daily supplemental folic acid intakes above the upper intake level (UL; 1000 µg/day). Daily dietary folate intakes were (mean (SD)) 575 (235) DFE µg/day. In contrast, only 24.8% of women met the dietary choline adequate intake (AI) recommendation (AI ≥ 450 mg/day) with a mean (SD) intake of 375 (151) mg/day. Further understanding of the impact of supplemental folic acid intake above the UL and low choline intake during pregnancy requires further investigation.

摘要

人们担心在低风险妊娠期间,女性摄入的叶酸补充剂超过了推荐量(400μg/天),并且可能无法满足其他营养素的推荐摄入量。本研究的目的是确定加拿大 CHILD 队列研究中(n=2996)妊娠中期(第 18 周)女性叶酸补充剂的使用情况和膳食叶酸摄入量。还评估了维生素 B12 和胆碱的摄入量,因为它们与叶酸在代谢上有关。大多数参与者(71.6%)正在服用每日产前补充剂。28%的女性(n=847)报告服用了叶酸补充剂,其中 45.3%的女性每日补充叶酸摄入量超过上限(UL;1000μg/天)。每日膳食叶酸摄入量(平均值(标准差))为 575(235)DFEμg/天。相比之下,只有 24.8%的女性满足膳食胆碱充足摄入量(AI)的推荐值(AI≥450mg/天),平均摄入量为 375(151)mg/天。需要进一步研究补充叶酸摄入量超过 UL 和妊娠期间低胆碱摄入量对健康的影响。

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Women in Canada are consuming above the upper intake level of folic acid but few are meeting dietary choline recommendations in the second trimester of pregnancy: data from the CHILD cohort study.加拿大女性摄入的叶酸超过了可耐受最高摄入量,但在妊娠中期,很少有人达到膳食胆碱的推荐摄入量:来自 CHILD 队列研究的数据。
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Mol Nutr Food Res. 2025 May;69(9):e70044. doi: 10.1002/mnfr.70044. Epub 2025 Mar 23.
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Dietary choline intake in European and non-european populations: current status and future trends-a narrative review.欧洲和非欧洲人群的膳食胆碱摄入量:现状和未来趋势——叙述性综述。
Nutr J. 2024 Jun 28;23(1):68. doi: 10.1186/s12937-024-00970-0.