2-5A的手性和非手性硫代磷酸酯类似物：酶促合成、表征及生物活性 - Suppr | 超能文献

Chiral and achiral phosphorothioate analogs of 2-5A: enzymatic synthesis, characterization, and biological activities.

作者信息

Suhadolnik R J, Lee C

出版信息

Prog Clin Biol Res. 1985;202:115-22.

Abstract

摘要

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Chemical synthesis and biological activities of partially inosine-substituted 2',5'-oligoadenylates: functional discrimination of three adenine amino groups on 2-5A for the binding to and activation of 2-5A-dependent endonuclease.部分肌苷取代的2',5'-寡腺苷酸的化学合成及生物活性：2-5A上三个腺嘌呤氨基对2-5A依赖性核酸内切酶结合与激活的功能区分

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Stereoconfiguration markedly affects the biochemical and biological properties of phosphorothioate analogs of 2-5A core, (A2'p5')2A.立体构型显著影响2-5A核心的硫代磷酸酯类似物（A2'p5')2A的生化和生物学特性。

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[Directed synthesis of 2',5'-oligoadenylates with increased stability towards phosphodiesterases].[对磷酸二酯酶稳定性增强的2',5'-寡腺苷酸的定向合成]

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