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通过纳米颗粒传递核酸来增强植物生物技术。

Enhancing plant biotechnology by nanoparticle delivery of nucleic acids.

机构信息

Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, Queensland 4072, Australia; Centre for Horticultural Science, Queensland Alliance for Agriculture and Food Innovation, The University of Queensland, St Lucia, Queensland 4072, Australia.

Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, Queensland 4072, Australia.

出版信息

Trends Genet. 2024 Apr;40(4):352-363. doi: 10.1016/j.tig.2024.01.005. Epub 2024 Feb 5.

Abstract

Plant biotechnology plays a crucial role in developing modern agriculture and plant science research. However, the delivery of exogenous genetic material into plants has been a long-standing obstacle. Nanoparticle-based delivery systems are being established to address this limitation and are proving to be a feasible, versatile, and efficient approach to facilitate the internalization of functional RNA and DNA by plants. The nanoparticle-based delivery systems can also be designed for subcellular delivery and controlled release of the biomolecular cargo. In this review, we provide a concise overview of the recent advances in nanocarriers for the delivery of biomolecules into plants, with a specific focus on applications to enhance RNA interference, foreign gene transfer, and genome editing in plants.

摘要

植物生物技术在现代农业和植物科学研究中起着至关重要的作用。然而,将外源遗传物质递送到植物中一直是一个长期存在的障碍。基于纳米颗粒的递药系统正在被建立起来以解决这一限制,并被证明是一种可行的、多功能的、有效的方法,可促进功能性 RNA 和 DNA 被植物内化。基于纳米颗粒的递药系统还可以被设计用于亚细胞内递药和生物分子货物的控制释放。在这篇综述中,我们简要概述了将生物分子递送到植物中的纳米载体的最新进展,特别关注应用于增强 RNA 干扰、外源基因转移和植物基因组编辑的方面。

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