College of Animal Science and Technology, Northeast Agricultural University, Harbin, Heilongjiang 150030, P. R. China.
J Agric Food Chem. 2024 Feb 21;72(7):3730-3740. doi: 10.1021/acs.jafc.3c08553. Epub 2024 Feb 6.
Increasing evidence indicates that maternal exposure to oxidized soybean oil (OSO) causes damage to the mother and offspring. The antioxidant resveratrol (Res) has a variety of health benefits. However, the protective effect of Res on mitigating offspring damage after maternal exposure to OSO and its mechanism remains unclear. Therefore, this study aimed to investigate the effect of Res on hepatic fatty acid metabolism and the jejunal barrier in suckling piglets after maternal OSO exposure. A total of 18 sows in late gestation were randomly assigned to three treatments. The sows were fed with a fresh soybean oil (FSO) diet, an OSO diet, or the OSO diet supplemented with 300 mg/kg Res (OSO + Res), respectively. The results showed that maternal supplementation of Res restored the mRNA levels of genes related to fatty acid metabolism and increased the activities of catalase (CAT) and total superoxide dismutase (T-SOD) in suckling piglets' livers under the OSO challenge. Moreover, the OSO + Res group restored the mRNA levels of occludin and claudin 4 in suckling piglet jejunum compared with the results of the OSO challenges. In summary, supplementation with Res improves hepatic fatty acid metabolism and intestinal barrier function of suckling piglets after maternal OSO challenge during late gestation and lactation.
越来越多的证据表明，母体暴露于氧化大豆油（OSO）会对母体和后代造成损害。抗氧化剂白藜芦醇（Res）具有多种健康益处。然而，Res 减轻母体暴露于 OSO 后后代损伤的保护作用及其机制尚不清楚。因此，本研究旨在探讨 Res 对母体 OSO 暴露后哺乳仔猪肝脏脂肪酸代谢和回肠屏障的影响。将 18 头妊娠晚期的母猪随机分为三组。母猪分别喂食新鲜大豆油（FSO）日粮、OSO 日粮或 OSO 日粮补充 300mg/kg Res（OSO+Res）。结果表明，母体补充 Res 恢复了脂肪酸代谢相关基因的 mRNA 水平，并在 OSO 挑战下增加了哺乳仔猪肝脏中过氧化氢酶（CAT）和总超氧化物歧化酶（T-SOD）的活性。此外，与 OSO 挑战的结果相比，OSO+Res 组恢复了哺乳仔猪空肠中闭合蛋白和 Claudin4 的 mRNA 水平。综上所述，在妊娠晚期和哺乳期，Res 的补充改善了母体 OSO 挑战后哺乳仔猪的肝脏脂肪酸代谢和肠道屏障功能。
