Department of Pharmaceutics, Faculty of Pharmacy, Kerman Medical Science University, Kerman, Iran.
Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
Curr Med Chem. 2024;31(27):4383-4391. doi: 10.2174/0109298673259596231211113211.
Iron chelators (ICs) have recently emerged as one of the new methods of treatment for viral infections. This study aimed to evaluate the efficiency and safety of natural ICs compared to synthetic ICs. Natural and synthetic ICs are the most common therapeutic agents tested for the treatment of viral infections. When evaluated against synthetic ICs, natural ICs are probably favored owing to their lower toxicity and safer properties. The main objective of the present systematic review was to assess the current evidence on the role of pharmacological mechanisms in the treatment of viral infections.
This study was designed as a systematic review in which search strategies were focused on two electronic databases, PubMed, and Scopus, between 2017 and 2021. A search filter with two subjects, "iron chelators" and "viral infection", was employed.
According to the results, both natural and synthetic chelators had a considerable impact on the treatment of viral infections various mechanisms, with natural ICs being the most extensively used.
Natural and synthetic ICs exert their effects through different pharmacological mechanisms. Among these compounds, natural chelators are more widely used due to their safety, efficacy, and a wider range of applications.
铁螯合剂（ICs）最近已成为治疗病毒感染的新方法之一。本研究旨在评估天然 IC 与合成 IC 的疗效和安全性。天然和合成 IC 是治疗病毒感染最常测试的治疗剂。与合成 IC 相比，天然 IC 可能因其毒性较低和安全性较高而受到青睐。本系统评价的主要目的是评估药理学机制在治疗病毒感染中的作用的现有证据。
本研究设计为系统评价，其中搜索策略集中在 2017 年至 2021 年期间的两个电子数据库 PubMed 和 Scopus 上。使用了一个包含两个主题的搜索过滤器，“铁螯合剂”和“病毒感染”。
根据结果，天然和合成螯合剂都通过不同的药理学机制对病毒感染的治疗产生了相当大的影响，其中天然 IC 应用最广泛。
天然和合成 IC 通过不同的药理学机制发挥作用。在这些化合物中，由于其安全性、有效性和更广泛的应用范围，天然螯合剂的应用更为广泛。
